Patients with sickle cell trait may experience mild if any, symptoms at all. In sickle cell disease, symptoms are more significant, especially in episodes of acute crisis. These symptoms can include: Generalized body aches and pain Chest pain Bone pain Shortness of breath Ulceration of the ...
a severe hereditary form ofanemiain which the cells become crescent-shaped when oxygen is lacking. The abnormal sickle-shaped cells die prematurely and may become lodged in small blood vessels, potentially obstructing the microcirculation and leading to tissue damage. The sickling trait is found main...
It may be said, then, that in the absence of a second disease process, asymptomatic patients with S-C hemoglobin disease are not anemic. This is so regardless of the absence of a history of symptoms referable to S-C hemoglobin disease. It is important to stress, however, that during peri...
of African descent. Infants are well at birth and develop hemolysis only afterHb Fproduction is replaced by Hb C. Patients generally haveHb levelsin the range of 9 to 12 g/dL withmicrocytosis. Clinical symptoms are largely absent, and most adults havesplenomegalythat is generally asymptomatic...
Patients with sickle cell trait may experience mild if any, symptoms at all. In sickle cell disease, symptoms are more significant, especially in episodes of acute crisis. These symptoms can include: Generalized body aches and pain Chest pain Bone pain Shortness of breath Ulceration of the ...
Summary and Conclusions: Sickle cell trait can be separated from hemoglobin S-C disease, S-thalassemia, and even sickle cell anemia only on the basis of ca... WF Mccormick - 《American Journal of the Medical Sciences》 被引量: 70发表: 1961年 Lupus nephritis in juvenile myelomonocytic leukemia...
(HbAA or HbSS). It appears that the heterozygous condition offers protection from parasites, particularlyPlasmodium falciparum, especially in children. When infected withP. falciparum, children with sickle cell trait have a lower parasite count, the infection is shorter in duration, and the incidence...
Conclusion The clinical course and blood cell counts of children with hemoglobin S/D-Punjab were very similar to those of hemoglobin SS children. In contrast, children with hemoglobin S-Korle Bu had clinical course and blood cell counts like children with the sickle cell trait 展开 ...
Hemoglobin (Hb)-SC disease results from a combination of sickle cell trait coinherited with the β-globin C trait. This results in a sickling condition with generally milder hemolytic anemia and less frequent acute and chronic complications. Sickle cell trait combined with a null β-globin ...
2. Some of the previous cases of sickle cell trait reported with symptoms of crisis and/or hematuria might well have been sickle cell hemoglobin-C disease. The literature is reviewed in this connection. 3. The finding of hematuria with sickle cell trait in a significant number of patients is...