cells die prematurely and may become lodged in small blood vessels, potentially obstructing the microcirculation and leading to tissue damage. The sickling trait is found mainly in people of African descent, though the disease also occurs in persons of Middle Eastern, Mediterranean, or Indian ...
In older infants, the amount of HbS will increase as HbF decreases. Hemoglobin A2 (HbA2) is a normal variant of hemoglobin A that consists of two alpha and two delta chains (α2δ2) and is found at low levels in normal human blood (1.5%–3.1% of all hemoglobin molecules in adults)...
When the mutation occurs on both chromosomes (chromosome 11), it produces sickle-cell disease; this has the most severe symptoms, since the RBC has no source of normal β-globin. With a mutation only on one chromosome (in heterozygotes), it produces sickle-cell trait (1 in 10 newborns);...
Psychosocial correlates of hemoglobin A1c in young adults with type I diabetes To determine whether psychosocial variables are related to long-term glycemic control; trait anxiety, depression, loneliness and life stress were assessed ... SJ Niemcryk,MA Speers,LB Travis,... - 《Journal of Psychos...
in only one of the two beta chains, resulting in sickle cell trait. Resistance to falciparum malaria infection and complications are benefits of a sickle cell trait. Homozygous individuals have mutations in both beta chains, resulting in sickle cell disease. When deoxygenated, HbS causes the ...
In the first family, born to AS parents, four c... SA Ali - 《Br J Haematol》 被引量: 73发表: 2010年 Sickle cell disease in a patient with sickle cell trait and compound heterozygosity for hemoglobin.. Describes a case in which unexplained clinical symptoms suggestive of sickle cell ...
Abnormal hemoglobin levels are not a diagnosis of any of these conditions. Instead, your hemoglobin levels are evaluated in the context of your symptoms, other blood counts, and additional test results to diagnose an underlying cause of high or low levels of hemoglobin. ...
Sickle Cell Trait This is a benign, carrier state, and the vast majority of individuals have no clinical symptoms. The incidence of the trait in U.S. blacks is 10%. In certain tribal areas of India the incidence approaches 30 %. Sickle cell trait can cause hematuria and a loss of urine...
The loss of two of the four genes is referred to asα-thalassemia trait.The pair of deleted genes may be from the same chromosome, or one α-globin gene may be deleted from each of the two chromosomes. The former situation is more common in Asian populations, whereas the latter is witne...
Infants are well at birth and develop hemolysis only after Hb F production is replaced by Hb C. Patients generally have Hb levels in the range of 9 to 12 g/dL with microcytosis. Clinical symptoms are largely absent, and most adults have splenomegaly that is generally asymptomatic. ...