Hemoglobin SE disease is caused by a copy of the hemoglobin S gene inherited from one parent and a copy of the hemoglobin E gene inherited from the other. People with hemoglobin E disease have a mild hemolytic anemia and mild splenomegaly. Hemoglobin E trait is benign. Hemoglobin E is ...
a severe hereditary form ofanemiain which the cells become crescent-shaped when oxygen is lacking. The abnormal sickle-shaped cells die prematurely and may become lodged in small blood vessels, potentially obstructing the microcirculation and leading to tissue damage. The sickling trait is found main...
Characterized by homozygosis for the hemoglobin S gene, the individual has a range of signs and symptoms that require careful treatment. The sickle cell trait is characterized by heterozygosis for the hemoglobin S gene, however the carrier does not express the disease. In the current study we...
variants associated with clinical symptoms (e.g., alteredoxygen affinity, unstable Hb) are important to identify precisely by the addition of morecomplex proteinmethods and genotyping, if needed. Owing to the small size of the humanglobingenes (three exons and two introns), these genomic loci...
Sickle cell trait describes the way a person can inherit some of the genes of sickle cell disease, but not develop symptoms. Sickle cell disease is a blood disorder in which the body produces an abnormal type of the oxygen-carrying substance hemoglobin in the red blood cells. Normal hemoglobin...
recently several unlinked genetic factors have been identified which elevate the HbF levels5. Four major quantitative trait loci (QTLs): the beta globin gene (HBB) locus, the B-cell lymphoma/leukemia 11A (BCL11A)gene, the HBS1 Like Translational GTPase-MYB Proto-Oncogene (HBSB1L-cMYB) inter...
Sickle cell disease in a patient with sickle cell trait and compound heterozygosity for hemoglobin.. Describes a case in which unexplained clinical symptoms suggestive of sickle cell disease were seen in an apparent carrier who had an electrophonetically s... Witkowska,E H.,Lubin,... - 《New...
A hemoglobin test is normally prescribed by a doctor, so talk with your health care provider if you have symptoms that could be related to abnormal hemoglobin levels. Can I take the test at home? There are options for at-home hemoglobin testing. At-home tests use one or more drops of bl...
Barash M, Reich KA, Rademaker D:Lidocaine-induced methemoglobinemia: a clinical reminder. J Am Osteopath Assoc. 2015, 115:94-98.10.7556/jaoa.2015.020 Shamriz O, Cohen-Glickman I, Reif S, Shteyer E:Methemoglobinemia induced by lidocaine-prilocaine cream. Isr Med Assoc J. 2014, 16:250-...
Background: β-thalassemia/HbE presents with a variety of clinical symptoms, from asymptomatic to severe, requiring routine transfusion. However, there is currently no agreed classification system to stratify patients based on clinical severity of β-thalassemia/HbE in the Indonesian population. Thailand...