2. GPX4 and ferroptosis 3. GPX4, ferroptosis, and diseases 4. Regulation of GPX4 in Disease 5. Summary and future prospects Funding CRediT authorship contribution statement Declaration of Competing Interest Acknowledgments Data Availability ReferencesShow full outline Cited by (38) Figures (4) Tables...
Ferroptosis has been implicated in many diseases and injuries. Therefore, Gpx4 could be a target of therapeutic development for diseases such as cancer and neurodegenerative diseases.QitaoRanPaulinaMozolewskaQitaoRanPaulinaMozolewska
摘要 Ferroptosis, a cell death process driven by iron-dependentphospholipidperoxidation, has been implicated in various diseases. There are two major surveillance mechanisms to suppress ferroptosis: one mediated byglutathione peroxidase4 (GPX4) that catalyzes the reduction of phospholipid peroxides and the ...
Although initially discovered as iron-dependent cell death in cancer cells [22], ferroptosis has recently been confirmed to play a crucial role in the pathogenesis of various human diseases, including systemic lupus erythematosus and rheumatoid arthritis [24, 25]. Moreover, the effects of ...
Ferroptosis as a therapeutic target for inflammation-related intestinal diseases [J]. Front Pharmacol, 2023, 14: 1095366. [7] Deng F, Zhao B C, Yang X, et al. The gut microbiota metabolite capsiate promotes Gpx4 expression by activating TRPV1 to inhibit intestinal ischemia reperfusion-induced...
However, the mechanism of the way by which EA inhibits ferroptosis is still obscure. Investigating the specific mechanism of EA for ischemic stroke is anticipated to yield a new scientific basis for targeted therapy of relevant neurological diseases in the future. The etiopathogenesis of ferroptosis ...
Ferroptosis is a novel form of regulated cell death (RCD) characterized by accumulation of iron-driven peroxidation of polyunsaturated fatty acids (PUFA), resulting in uncontrollable redox reaction, and ultimately, cell death4, 5, 6. As a unique type of RCD, ferroptosis is morphologically, ...
Ferroptosis and its role in diverse brain diseases. Mol Neurobiol. 2019;56:4880–93. Article CAS Google Scholar Qu Y, Wang J, Ray PS, Guo H, Huang J, Shin-Sim M, et al. Thioredoxin-like 2 regulates human cancer cell growth and metastasis via redox homeostasis and NF-κB signaling. ...
Ferroptosis requires acyl-CoA synthetase long-chain family member 4 (ACSL4)-mediated membrane enrichment of the ω-6 PUFA arachidonic acid (AA), which is prone to oxidation2,6,7. Deletion of both alleles of Gpx4 culminates in organ injury of the kidney, brain, and skin, which is ...
The ferroptosis-related SLC7A11/GSH/GPX4 pathway was repressed in MI/RI rat myocardial tissues, inducing myocardial injury. H/R affected GSH synthesis and inhibited GPX4 enzyme activity by down-regulating SLC7A11, thus promoting ferroptosis in cardiomyocytes, which was averted by Lip-1. SLC7A11 ...