Sensitivity profiling in 177 cancer cell lines revealed that diffuse large B cell lymphomas and renal cell carcinomas are particularly susceptible to GPX4-regulated ferroptosis. Thus, GPX4 is an essential regul
Cell 156, 317-331Yang, W.S., et al., Regulation of ferroptotic cancer cell death by GPX4. Cell, 2014. 156(1-2): p. 317-31.Yang WS, SriRamaratnam R, Welsch ME, Shimada K, Skouta R, Viswanathan VS, et al. Regulation of ferroptotic cancer cell death by GPX4. Cell. 2014; ...
Regulation of ferroptotic cancer cell death by GPX4. Cell. 2014;156:317–31. Article CAS PubMed PubMed Central Google Scholar Wu J, Minikes AM, Gao M, Bian H, Li Y, Stockwell BR, et al. Intercellular interaction dictates cancer cell ferroptosis via NF2–YAP signalling. Nature. 2019;...
来源期刊 Cell Cambridge Ma 研究点推荐 GPX4 Ferroptotic Cancer Cell 引用走势 2017 被引量:96 站内活动 0 关于我们 百度学术集成海量学术资源,融合人工智能、深度学习、大数据分析等技术,为科研工作者提供全面快捷的学术服务。在这里我们保持学习的态度,不忘初心,砥砺前行。了解更多>> 友情链接 联系我们 ...
et al. Regulation of ferroptotic cancer cell death by GPX4. Cell 156, 317–331 (2014). CAS PubMed PubMed Central Google Scholar Friedmann Angeli, J. P. et al. Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. Nat. Cell. Biol. 16, 1180–1191 (2014...
S. et al. Regulation of ferroptotic cancer cell death by GPX4. Cell 156, 317–331 (2014). 5. Doll, S. et al. FSP1 is a glutathione-independent ferroptosis sup- pressor. Nature 575, 693–698 (2019). 6. Bersuker, K. et al. The CoQ oxidoreductase FSP1 acts parallel to GPX4 to...
Although the underling mechanism leading to ferroptosis is not yet fully understood, compelling evidence suggests that GPx4 is a key regulator of ferroptotic cell death [14,16,17]. The GPx protein family consists of eight isozymes, characterised by distinct tissue distribution, subcellular ...
Regulation of ferroptotic cancer cell death by GPX4. Cell. 2014;156:317–31. 54. Chen MS, Wang SF, Hsu CY, Yin PH, Yeh TS, Lee HC, et al. CHAC1 degradation of glutathione enhances cystine-starvation- induced necroptosis and ferroptosis in human triple negative breast cancer cells via ...
Ferroptosis is a newly discovered form of cell death that is featured in a wide range of diseases. Exosome therapy is a promising therapeutic option that has attracted much attention due to its low immunogenicity, low toxicity, and ability to penetrate b
GPX4 is the sole known mammalian selenoprotein that utilizes glutathione (GSH) as a co-factor to convert toxic lipid hydroperoxides (L-OOH) on the cytoplasmic membrane to non-toxic lipid alcohols (L-OH), thus protecting cells from ferroptotic cell death12,13,14. The functional significance o...