SignalingCellularGrowth,ProliferationandDevelopment;CellularImmuneResponse;CytokineSignaling;GrowthFactorSignaling Pathway Categories TopFunctionsCellularDevelopment;CellularGrowthandProliferation;HematologicalSystemDevelopmentandFunction Diseases MoleculesactivationofTlymphocytes,Akt,BCL2A1,BCL2L1,Ca2+,CalcineurinA,CalcineurinA...
atedbytheGM-/M-CSFsignalingaxisinhumanmonocytes[J].CellRe p,2019,29(4):860-872.e5.DOI:10.1016/j.celrep.2019.09.035. [13]AchuthanA,AslamA,NguyenQ,etal.Glucocorticoidspromoteap optosisofproinflammatorymonocytesbyinhibitingERKactivity[J].C ...
namely, proinflammatory M1-like MØs and immunosuppressive M2-like MØs. Despite the importance of these opposing biological outcomes, the intrinsic mechanism that regulates the functional polarization of MØs under GM-CSF
We focused on the effects of GM-CSF signaling given the availability of biological tools available to probe this signaling axis in human macrophages. GM-CSF has long been known as a critical hematopoietic growth factor; however, recent studies have identified a role for GM-CSF in homeostatic and...
521 GM-CSF Signaling in Intestinal Epithelial Cells Regulates Ileal Barrier FunctionIleal involvement in Crohn's disease (CD) is associated with NOD2 mutations and granulocyte-macrophage colony stimulating factor autoantibodies (GM-CSF Ab), and GM-CSF blockade promotes ileitis in Nod2/Card15-...
GM-CSF synergizes with LPS for IL-1β secretion mainly at the level of pro-IL-1β production via strengthening the NF-κB signaling. In addition, we show that expression of Rab39a, a GTPase required for caspase-1 dependent IL-1β secretion is greatly augmented by LPS and GM-CSF co-...
cascade bioscience | cayman | cayman chemical | CDN | cedarlane | cedarlanelabs | celartia | celex | cell biolabs | cell marque | Cell Point Scientific | cell projects | cell sciences | cell signaling | cell signaling technology | Cell Signaling Technology (CST) | Cell Signaling Technology, ...
Human granulocyte-macrophage colony-stmulating factor (GM-CSF) both stimulates hematopoietic precursor cells to grow as well as enhances the function of mature effector cells, such as neutrophils, eosinophils and macrophages. All of the biological actions of GM-CSF appear to be mediated via binding...
van der Pouw K T, Snoek M, de Boer M, et al. "Proinflammatory cytokines and the IL-12/IL-23 p40-signaling pathway in atopic dermatitis and psoriasis." Journal of Allergy and Clinical Immunology, 2010, 125(4): 879-887. Eagle Biosciences是一家为研究人员和临床实验室提供免疫测定、抗体和蛋...
A. GM-CSF- and M-CSF-dependent macrophage phenotypes display differential dependence on type I interferon signaling. J. Leukoc. Biol. 86, 411–421 (2009). Article CAS PubMed Google Scholar Akagawa, K. S. et al. Functional heterogeneity of colony-stimulating factor-induced human monocyte-...