GM-CSF缺乏的小鼠成熟AM的数量显著减少,黏附能力、免疫功能降低、细胞表面受体表达减少、对表面活性物质的摄取、清除能力降低,导致脂蛋白等物质在细胞内大量蓄积[14 , 15 , 16 ]。GM-CSF缺乏的巨噬细胞表面受体表达减少,如承担固有免疫功能的模式识...
该研究结论认为,CSF3R评估有助于识别可能从G-CSF治疗中受益的肝硬化患者,而通过中和抗体对CEACAM-1进行阻断可能是一种改善CSF3R表达和功能的潜在策略。 本文“CEACAM-1 Induced CSF3-receptor Downregulation in Bone Marrow Associate...
GM-CSF: receptor structure and transmembrane signaling. Int J Cell Cloning 1990;8:63-75.DiPersio JF, Golde DW, Gasson JD. GM- CSF: receptor structure and transmembrane signaling. Int J Cell Cloning. 1990;8(Suppl 1):63-74; discussion, 75....
24ezekowitz,r.a.和gordon,s.《在卡介苗激活的小鼠巨噬细胞中甘露糖基受体介导的内吞和抗原f4/80的下调:t淋巴细胞和淋巴因子的作用(down-regulationofmannosylreceptor-mediatedendocytosisandantigenf4/80inbacilluscalmette-guerin-activatedmousemacrophages.roleoftlymphocytesandlymphokines)》,jexpmed155,1623-1637(1982...
粒-巨噬细胞集落刺激因子(granulocyte-macrophage colony-stimulating factor,GM-CSF)为造血生长因子家族成员,通过细胞膜表面特异性受体(GM-CSF receptor,GMR)介导维持细胞存活,刺激细胞增殖与分化,,调节成熟细胞功能.人和小鼠GM-CSF分别由144和141氨基酸残基组成,均包含17氨基酸的先导序列.成熟的人和小鼠GM-CSF分子分别由...
GM-CSFreceptorfamily.CellSignal.10,619-628.deVries,E.G"Willemse,RH"Biesma,B"Stern,A.C.,Limburg,P.C.及Vellenga,E.(1991).Flare-upofrheumatoidarthritisduringGM-CSFtreatmentafterchemotherapy.Lancet338,517-518.Diederichs,K.,Boone,T.及Karplus,RA.(1991).Novelfoldandputativereceptorbindingsiteof...
粒细胞-巨噬细胞集落刺激因子(GM-CSF)粒细胞-巨噬细胞集落刺激因子(GM-CSF),也称为集落刺激因子2(CSF2),是单体糖蛋白,通过分泌巨噬细胞,T细胞,肥大细胞,自然杀伤细胞,内皮细胞和成纤维细胞,其功能如同一个细胞因子。不同于粒细胞集落刺激因子,它特别促进嗜中性粒细胞的增殖和成熟,GM-CSF影响更多的细胞类型...
GM-CSF-receptor is increased on HSCs and multipotent progenitors, favoring a striking increase in myelopoiesis at the earliest hematopoietic stages. GMP accumulate in the BM in SpA and, unexpectedly, at extramedullary sites: in the inflamed joints and spleen. Furthermore, we show that GM-CSF ...
Characterisation of the expression and function of the GM-CSF receptor alpha-chain in mice. Eur J Immunol 2007;37:2518-28.Rosas M, Gordon S, Taylor PR. Characterisation of the expression and function of the GM-CSF receptor alpha-chain in mice. Eur J Immunol. Sep.2007 37:2518. [PubMed...
粒-巨噬细胞集落刺激因子(granulocyte-macrophage colony-stimulating factor,GM-CSF)为造血生长因子家族成员,通过细胞膜表面特异性受体(GM-CSF receptor,GMR)介导维持细胞存活,刺激细胞增殖与分化,,调节成熟细胞功能.人和小鼠GM-CSF分别由144和141氨基酸残基组成,均包含17氨基酸的先导序列.成熟的人和小鼠GM-CSF分子分别由...