[4] Kitamura T, Hayashida K, Sakamaki K, et al. Reconstitution of functional receptors for human granulocyte/macrophage colony-stimulating factor (GM-CSF): evidence that the protein encoded by the AIC2B cDNA is a subunit of the murine GM-CSF receptor. Proceedings of the National Academy of ...
GM-CSF缺乏的巨噬细胞表面受体表达减少,如承担固有免疫功能的模式识别受体:甘露糖受体、Toll样受体4(Toll-like receptor 4,TLR4),TLR2等[14 ]。缺乏GM-CSF的巨噬细胞不能有效地吞噬杀死病原体,不能抑制细菌的增殖。实验显示,大肠埃希菌和链球菌...
[4] Kitamura T, Hayashida K, Sakamaki K, et al. Reconstitution of functional receptors for human granulocyte/macrophage colony-stimulating factor (GM-CSF): evidence that the protein encoded by the AIC2B cDNA is a subunit of the murine GM-CSF receptor. Proceedings of the National Academy of S...
近年来,CSF2(粒细胞-巨噬细胞集落刺激因子,GM-CSF)在生物医学领域的研究备受瞩目。CSF2在免疫调节、炎症反应和肿瘤进展等过程中扮演着关键角色,这使其在多种疾病的治疗中展现出潜在的临床应用价值 [1]。2023…
当肝硬化患者出现血细胞减少症尤其是难治性中性粒细胞减少症(Refractory Neutropenia)后,通常对患者进行外源性粒细胞集落刺激因子(G-CSF)的注射治疗。这是因为就机制而言,G-CSF可以促进造血干细胞的募集和中心粒细胞的生成。但是,G-...
ReceptorLeukotrienesPlatelet-activating factorHuman granulocyte-macrophage colony-stmulating factor (GM-CSF) both stimulates hematopoietic precursor cells to grow as well as enhances the function of mature effector cells, such as neutrophils, eosinophils and macrophages. All of the biological actions of GM...
receptor modulationA quantitative analysis of expression levels of GM-CSF receptors was performed by flow cytometry in different disease categories, ie AML (n = 72), ALL (n = 18), and MDS (n = 12), as well as 12 healthy volunteers, using three different unconjugated GM-CSF/R monoclonal ...
及Koenderman,L.(1998).Regulationofproliferation,differentiationandsurvivalbytheIL-3/IL-5/GM-CSFreceptorfamily.CellSignal.10,619-628.deVries,E.G"Willemse,RH"Biesma,B"Stern,A.C.,Limburg,P.C.及Vellenga,E.(1991).Flare-upofrheumatoidarthritisduringGM-CSFtreatmentafterchemotherapy.Lancet338,517-518....
粒-巨噬细胞集落刺激因子(granulocyte-macrophage colony-stimulating factor,GM-CSF)为造血生长因子家族成员,通过细胞膜表面特异性受体(GM-CSF receptor,GMR)介导维持细胞存活,刺激细胞增殖与分化,,调节成熟细胞功能.人和小鼠GM-CSF分别由144和141氨基酸残基组成,均包含17氨基酸的先导序列.成熟的人和小鼠GM-CSF分子分别由...
. The receptor for GM-CSF (GM-CSFR) is composed of two subunits: the cytokine-specific α subunit (GMRα; CD116) and the common subunit βc (CD131) shared with IL-3 and IL-5 receptors (Broughton et al.). GM-CSFR is expressed on hematopoietic cells, including progenitor cells and ...