总之,我们的研究结果揭示了一种CIS调节机制,该机制阐明了GM-CSF在MØ分化中的相反作用,并揭示了GM-CSF在控制过敏性炎症中的作用。 英文摘要 The cytokine granulocyte-macrophage-colony stimulating factor (GM-CSF) possesses the capacity to dif...
GM-CSFReceptorLeukotrienesPlatelet-activating factorHuman granulocyte-macrophage colony-stmulating factor (GM-CSF) both stimulates hematopoietic precursor cells to grow as well as enhances the function of mature effector cells, such as neutrophils, eosinophils and macrophages. All of the biological actions...
GM-CSF synergizes with LPS for IL-1β secretion mainly at the level of pro-IL-1β production via strengthening the NF-κB signaling. In addition, we show that expression of Rab39a, a GTPase required for caspase-1 dependent IL-1β secretion is greatly augmented by LPS and GM-CSF co-...
We focused on the effects of GM-CSF signaling given the availability of biological tools available to probe this signaling axis in human macrophages. GM-CSF has long been known as a critical hematopoietic growth factor; however, recent studies have identified a role for GM-CSF in homeostatic and...
In summary, our study outlines the contribution of non-coding variants in neutrophil GM-CSF signaling and the potential importance ofandin CD pathogenesis.doi:10.1038/s41598-019-45701-2Suresh VenkateswaranLee A. DensonIngrid JurickovaAnne Dodd...
In its monomeric form, GM-CSF acts as a signaling molecule, orchestrating complex receptor assemblies. GM-CSF Protein, Human (HEK293) is the recombinant human-derived GM-CSF protein, expressed by HEK293 , with tag free. 研究背景 GMP GM-CSF 蛋白作为关键细胞因子发挥作用,促进不同谱系的造血前体...
GM-CSF is a survival factor for and activates the effector functions of granulocytes, monocytes/macrophages, and eosinophils (1, 2). GM-CSF promotes a Th1 biased immune response, angiogenesis, allergic inflammation, and the development of autoimmunity (3‑5). It shows clinical effectiveness in ...
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Results The GM-CSF signaling pathway molecular signature was confirmed to be upregulated by 4 independent analyses. GM-CSF-associated and T H 1-associated genes were upregulated in GCA biopsies versus control (GMCSF: 3-4x RS; GM-CSF-R伪: 6.7x NS, 6x RS; and CD83: 3.9x NS, 6x RS; ...