signaling pathways, such as Akt and also the Janus family kinase-2 and signal transducer and activation of transcription-3 (Jak2-STAT3) pathway, thereby promoting survival, proliferation, differentiation and mobilisation of haematopoietic stem and progenitor cells. G-CSF is a cytokine that have been...
To begin to define the role of granulocyte colony-stimulating factor (G-CSF) in the regulation of hematopoiesis, Lieschke and colleagues generated G-CSF/(knockout) mice [1]. Knockout mice are...doi:10.1007/978-3-0348-0218-5_3Daniel C LinkSpringer BaselMilestones in Drug Therapy...
Colony-stimulating factors are cytokines. They work by activated intracellular (cell-to-cell) signaling pathways. This causes the targeted cells to proliferate and differentiate into specific kinds of cells. As mentioned, the specific kinds of cells resu
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binding with its receptor expressed by cardiomyocytes after an ischemic injury, directly activates prosurvival signaling.25Although G-CSF has been consistently confirmed in experimental animal models to act as a regenerative and cardioprotective drug af...
integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. It also plays a protective role after myocardial infarction, induces down-regulation and internalization of ACKR3 expressed in various cells and stimulates the ...
产品类型:多因子检测 品牌:Thermo Fisher 货号:EPX01A-26034-901 规格:96 tests 价格:1 物种:小鼠 宿主:其它 抗体亚型:其它 荧光染料:其它 产品介绍 技术参数 相关产品 产品介绍 Immunoassay Kit Grade:Simplex Kit 测定范围:As determined for Lot 1: 1.4-5850 pg/mL ...
产品类型:多因子检测 品牌:Thermo Fisher 货号:EPX01A-12001-901 规格:96 tests 价格:1 物种:人 宿主:其它 抗体亚型:其它 荧光染料:其它 产品介绍 技术参数 相关产品 产品介绍 Immunoassay Kit Grade:Simplex Kit 测定范围:As determined for Lot 1: 16.46-67400 pg/mL ...
immune responsemulticellular organism developmentpositive regulation of cell proliferationpositive regulation of phosphatidylinositol 3-kinase signalingcytokine-mediated signaling pathwaypositive regulation of actin filament polymerizationgranulocyte differentiationpositive regulation of protein bindingpositive regulation of pe...
immune responsemulticellular organism developmentpositive regulation of cell proliferationpositive regulation of phosphatidylinositol 3-kinase signalingcytokine-mediated signaling pathwaypositive regulation of actin filament polymerizationgranulocyte differentiationpositive regulation of protein bindingpositive regulation of pe...