CSF-1 regulation of the wandering macrophage: complexity in action. Trends Cell Biol. 2004;14:628–38. Article CAS Google Scholar Stanley ER, Chitu V. CSF-1 receptor signaling in myeloid cells. Cold Spring Harb
Many risk genes for the development of Alzheimer's disease (AD) are exclusively or highly expressed in myeloid cells. Microglia are dependent on colony-stimulating factor 1 receptor (CSF1R) signaling for their survival. We designed and synthesized a highly selective brain-penetrant CSF1R inhibitor ...
Chitu CSF-1 receptor signaling in myeloid cells Cold Spring Harb. Perspect. Biol., 6 (2014) Google Scholar Steinwede et al., 2011 K. Steinwede, O. Tempelhof, K. Bolte, R. Maus, J. Bohling, B. Ueberberg, F. Länger, J.W. Christman, J.C. Paton, K. Ask, et al. Local ...
CSF-1 receptor (CSF1R) signaling is important for the recruitment of CD11b+F4/80+ tumor-associated macrophages (TAMs) and contributes to myeloid cell-mediated angiogenesis. However, the impact of the CSF1R signaling pathway on other TIM subsets, including CD11b+Gr-1+ myeloid-derived suppressor...
CSF-1 receptor signaling in myeloid cells. The CSF-1 receptor (CSF-1R) is activated by the homodimeric growth factors colony-stimulating factor-1 (CSF-1) and interleukin-34 (IL-34). It plays importa... ER Stanley,V Chitu - 《Cold Spring Harb Perspect Biol》 被引量: 137发表: 2014年...
through its receptor tyrosine kinase CSF1R (cFMS) (17, 18). We recently showed that TAMs and MDSCs form a spectrum of bone marrow-derived myeloid cells dependent on CSF1/CSF1R signaling for recruitment into the tumor and that they play critical roles in tumor growth (15). DeNardo et al...
CSF-1 receptor signaling in myeloid cells. Signal TransductionProtein ConformationThe CSF-1 receptor (CSF-1R) is activated by the homodimeric growth factors colony-stimulating factor-1 (CSF-1) and ... ER Stanley,V Chitu - 《Cold Spring Harb Perspect Biol》 被引量: 137发表: 2014年 加载更多...
[0136] 8.史丹利ER,千图V(Chitu V):骨髓细胞中的CSF‑1受体信号传导(CSF‑1receptor signaling in myeloid cells).冷泉港生物学观点(Cold Spring Harb Perspect Biol) 2014;6. [0137] 9.佩德森MB,丹尼尔森AV(Danielsen AV),汉密尔顿‑杜托伊特SJ(Hamilton‑ Dutoit SJ),本迪克斯K(Bendix K),诺加德P(...
Elmore MR, Najafi AR, Koike MA et al (2014) Colony-stimulat- ing factor 1 receptor signaling is necessary for microglia viability, unmasking a microglia progenitor cell in the adult brain. Neuron 82(2):380–397. https://doi.org/10.1016/j.neuron.2014.02....
predisposition to myeloid malignancy.Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and ...