DGIdb数据库(Drug-Gene Interaction database),是一个药物-基因相互作用数据库,提供了基因与其已知或潜在药物关联信息,目前已经更新到4.0版本。里面的基因主要是癌基因,但是也有一些其他疾病(例如阿尔兹海默病、心脏病、糖尿病等)的相关基因。DGIdb一共有超过14000种药物-基因的相互作用,涉及2600个基因和6300中靶向这些...
The Drug-Gene Interaction Database (DGIdb, www.dgidb.org) is a web resource that provides information on drug-gene interactions and druggable genes from publications, databases, and other web-based sources. Drug, gene, and interaction data are normalized and merged into conceptual groups. The inf...
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More Data Sought on Drug-Gene Interaction
Drug-gene interaction between the insertion/deletion polymorphism of the angiotensin-converting enzyme gene and antihypertensive therapy. 来自 国家科技图书文献中心 喜欢 0 阅读量: 34 作者: Schelleman,H. 摘要: BACKGROUND: Despite the availability of a variety of effective drugs, inadequate control of...
Considering that the identification of cancer driver genes is required for cancer treatment, we used the drug–genes interaction database (DGIdb) [59] and TARGET database [60] to determine whether our candidate driver genes are clinically relevant genes. The results are shown in Fig.3. In all...
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Aim:To characterize concordance between clinically relevant drug–drug interactions (DDIs) related to CYP2C19, CYP2D6 and CYP2C9 and their analogous gene–drug interactions (GDIs) in US FDA-approved drug labeling.Methods:We selected prototypical CYP2C19, CYP2D6 and CYP2C9 inhibitors and abstracted...
Benchmarking Blockchain-Based Gene-Drug Interaction Data Sharing Methods: A Case Study from the iDASH 2019 Secure Genome Analysis Competition Blockchain Track - tsungtingkuo/genedrug
repositioning. By accumulating testing data, cutoff values forRgenein various cases can be determined to investigate the drug repositionability. Furthermore, since various drug combinations were tested in some clinical trials,Rgenewill be applicable for the studies of pharmacodynamic drug interaction. ...