As pharmacogenomic (PGx) testing increases in popularity, lay concepts of drug-gene interactions set the stage for shared decision making in precision medicine. Few studies explore what recipients of PGx results think is happening in their bodies when a drug-gene interaction is discovered. To ...
What is the human genome, and how would one explain it using haploids and chromosomes? What is a mutation that results in the addition of nucleotide pairs in a gene called? What is responsible for albinism in terms of DNA? What does DNA ligase do during DNA replication, and what is DNA...
E. et al. Molecular cloning and characterization of NKT, a gene product related to the organic cation transporter family that is almost exclusively expressed in the kidney. J. Biol. Chem. 272, 6471–6478 (1997). CAS PubMed Google Scholar Smith, H. W., Finkelstein, N., Aliminosa, L....
The Rhipicephalus (Boophilus) microplus Bm86 gene plays a critical role in the fitness of ticks fed on cattle during acute Babesia bovis infection BACKGROUND: Rhipicephalus (Boophilus) microplus is an economically important tick of cattle involved in the transmission of Babesia bovis, the etiologic...
Is non-small cell lung cancer hereditary? A hereditary family history of lung cancer is one of the many risk factors for developing non-small cell lung cancer. About 8% of lung cancers are thought to be inherited or linked to gene changes, but smoking and air pollution remain the primary ...
This article is an in-depth exploration of the promise and peril of generative AI: How it works; its most immediate applications, use cases, and examples; its limitations; its potential business benefits and risks; best practices for using it; and a glimpse into its future. ...
In short, AI in drug discovery needs quantitative variables and labels that are meaningful, but we are often insufficiently able to determine which variables matter, to define them experimentally (and on a large enough scale) and to label the biology for AI to succeed on a level that is ...
et al. Dietary intervention impact on gut microbial gene richness. Nature 500, 585–588 (2013). Article CAS PubMed Google Scholar Hildebrandt, M. A. et al. High-fat diet determines the composition of the murine gut microbiome independently of obesity. Gastroenterology 137, 1716–1724 (2009)...
Factors that affect the qt interval Although it is convenient to think of QT prolongation as occurring because of either congenital or acquired abnormalities, the phenomenon probably most often involves a gene-environment interaction. Pure congenital prolongation characterized by lifelong, ambient QT prolon...
Transcription initiation is a major regulatory step in eukaryotic gene expression. It involves the assembly of general transcription factors and RNA polymerase II into a functional pre-initiation complex at core promoters. The degree of chromatin compaction controls the accessibility of the transcription ...