Results: At baseline, 79 of 94 participants (84%) had at least one predicted major drug‐ gene interaction, and all 94 (100%) had at least one predicted moderate interaction. For the 44 participants who completed a survey of their symptoms at 6 months, the mean (SD) irritable bowel ...
β-actin was used as an internal reference gene. The results were analyzed using 2−△△ct. The primer premier 5.0 software was used to design all of the primers that were involved in the study. The primer sequences are shown in Table 5. Table 5 Primer sequence Full size table Data ...
Results showed a significant drug  gene interaction on RVIP probability of Neuropsychopharmacology Cannabis, genes, and cognition A Verdejo-Garcia et al 1602 Table 3 Neuropsychological Performance as a Function of Drug- Use Status: Cannabis Users vs Controls Cannabis (n ¼ 86) Control F P-...
The significant interaction between the 35% increase in physical activity andAPOEon executive functioning (B = 1.22,p = .003,d = 0.51) indicates that increasing physical activity with ≥ 35% leads to greater improvement in executive functioning for those with ApoE-ε4 (B =...
Multidrug resistance (MDR) caused by the overexpression of the MDR-1 gene that encodes P-glycoprotein (P-gp) is a critical mechanism of drug resistance which results in a cross-resistance to multiple classes of drugs28,29. A large number of commonly used chemotherapy drugs like taxanes and ...
Software analysis of gene expression in cells exposed to 0.23–0.28 T SMF showed that nine signaling networks responded to SMF; of these, detailed biochemical validation was performed for the network linked to the inflammatory cytokine IL-6. We found the short-term (<24 h) activation of IL-6...
In recent years, important insights into the pathogenesis of AD have been observed; this aspect was evidently reflected in drug therapy; in particular the moderate-severe forms are those in which we have had the greatest therapeutic innovations. The purpose of this narrative review was to update ...
MME is also implicated in neutrophil degranulation,59 and our list of informative model features contained multiple other proteins involved in neutrophil degranulation (protein pathway identified by Reactome; see STAR Methods; Reactome gene set identifier R-HSA-6798695.2; Figure S11A), which were ...
Chitosan-functionalized graphene oxide as a nanocarrier for drug and gene delivery. Small 7(11), 1569–1578 (2011). 10. Li, B. et al. Direct optical imaging of graphene in vitro by nonlinear femtosecond laser spectral reshaping. Nano Lett. 12(11), 5936–5940 (2012). 11. Shao, Y. ...
Gene expression was analysed according to the -D/Dct- method normalizing the individual mRNA amount to 18S and the mean mRNA amount in the untreated wildtype. In each graph the D/Dct amount is given on the left y-axis while the corresponding fold change in expression is given on the ...