Finally, using the best modularity resolution found with our method, we applied our pipeline to the latest DrugBank drug–gene interaction data to generate a comprehensive drug repurposing hint list. Keywords: bioinformatics; drug repurposing; complex network analysis; modularity clustering; ATC code 1...
Our method builds a drug–gene interaction network with drug–gene interaction data from the earlier DrugBank 5.0.9 version, then projects it as a drug–drug similarity network; this is the first drug repurposing method derived from a gene-based drug–drug similarity network to the best of our...
physiologically based pharmacokinetic (PBPK) modeling; clopidogrel; clopidogrel acyl glucuronide; clopidogrel active metabolite; drug–gene interaction (DGI); drug–drug interaction (DDI); cytochrome P450 2C8 (CYP2C8); cytochrome P450 2C19 (CYP2C19); mechanism-based inactivation; model-informed drug ...