DGIdb数据库(Drug-Gene Interaction database),是一个药物-基因相互作用数据库,提供了基因与其已知或潜在药物关联信息,目前已经更新到4.0版本。里面的基因主要是癌基因,但是也有一些其他疾病(例如阿尔兹海默病、心脏病、糖尿病等)的相关基因。DGIdb一共有超过14000种药物-基因的相互作用,涉及2600个基因和6300中靶向这些...
Access the world’s pharmaceutical knowledge database. Information on drugs, drug targets, and more, used by researchers and health professionals globally.
master BranchesTags Code Folders and files Name Last commit message Last commit date Latest commit History 2,920 Commits .github/workflows app bin config data db files lib log public spec text tmp tours .gitignore .rspec .ruby-version
More Data Sought on Drug-Gene Interaction
ingredient; (4) the provision of bioassay data for herbal ingredients, which can be used to study hidden activity-related information using cheminformatics methods; (5) the establishment of an herb-component-target-drug multilevel interaction network of TCM for deeper study of the mechanism of ...
repositioning. By accumulating testing data, cutoff values forRgenein various cases can be determined to investigate the drug repositionability. Furthermore, since various drug combinations were tested in some clinical trials,Rgenewill be applicable for the studies of pharmacodynamic drug interaction. ...
Fig. 4: Multi-omics factor analysis identifies shared factors linking morphology, gene expression and drug activity. a, b Variance decomposition of the MOFA model. Untreated organoid morphology, organoid size and drug activity scores were integrated with DNA sequencing and mRNA expression data. Source...
Benchmarking Blockchain-Based Gene-Drug Interaction Data Sharing Methods: A Case Study from the iDASH 2019 Secure Genome Analysis Competition Blockchain Track - tsungtingkuo/genedrug
Five databases were used, either programmatically or manually:The Drug-Gene Interaction database(DGIdb) Nov 2020, v4.2.045;Comparative Toxicogenomics Database(CTD), Oct 202046;The Binding Database(BindingDB), Nov 202047;PanDrugs, version: 2018.11.748; andPharos, version 3.2.049. To exploit pu...
the colon, stimulating CD8+T cells and Th1 cells, thus enhancing the infiltration of interferon (IFN)-γ-producing γδT cells into tumors.238The interaction between IVDR of CTX and the microbiota is complex, as CTX affects the intestinal barrier integrity, resulting in the translocation of ...