DGIdb数据库(Drug-Gene Interaction database),是一个药物-基因相互作用数据库,提供了基因与其已知或潜在药物关联信息,目前已经更新到4.0版本。里面的基因主要是癌基因,但是也有一些其他疾病(例如阿尔兹海默病、心脏病、糖尿病等)的相关基因。DGIdb一共有超过14000种药物-基因的相互作用,涉及2600个基因和6300中靶向这些...
The Drug-Gene Interaction Database (DGIdb, www.dgidb.org) is a web resource that provides information on drug-gene interactions and druggable genes from publications, databases, and other web-based sources. Drug, gene, and interaction data are normalized and merged into conceptual groups. The inf...
et al. Integration of the Drug–Gene Interaction Database (DGIdb) with open crowdsource efforts. Preprint at biorxiv https://doi.org/10.1101/2020.09.18.301721 (2020). Article Google Scholar Manolio, T. A. et al. Finding the missing heritability of complex diseases. Nature 461, 747–753 (...
Drug Gene Interaction Database (DGIdb) web resource43 was used to retrieve FDA-approved drugs that interact with 25 genes including the top ranked nodes of the core network (Table 2) and the identified TFs. We found 10 out of the 25 genes (7 upregulated DEGs and 3 TFs) have 64 intera...
In the third type of mechanism, which is peculiar tosteroid hormonesand related drugs, the steroid binds to a receptor that consists primarily of nuclear proteins. Because this interaction occurs inside the cell, agonists for this receptor must be able to cross the cell membrane. The drug-recept...
More Data Sought on Drug-Gene Interaction
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Benchmarking Blockchain-Based Gene-Drug Interaction Data Sharing Methods: A Case Study from the iDASH 2019 Secure Genome Analysis Competition Blockchain Track - tsungtingkuo/genedrug
repositioning. By accumulating testing data, cutoff values forRgenein various cases can be determined to investigate the drug repositionability. Furthermore, since various drug combinations were tested in some clinical trials,Rgenewill be applicable for the studies of pharmacodynamic drug interaction. ...
(CTD)13or Drug-Gene Interaction Database (DGIdb)27provide valuable resources regarding DGIs and their association types (e.g. acetylation, methylation, phosphorylation), to our knowledge these resources have not been used to predict potential DDIs and associated ADR types in common practice. We ...