DGIdb数据库(Drug-Gene Interaction database),是一个药物-基因相互作用数据库,提供了基因与其已知或潜在药物关联信息,目前已经更新到4.0版本。里面的基因主要是癌基因,但是也有一些其他疾病(例如阿尔兹海默病、心脏病、糖尿病等)的相关基因。DGIdb一共有超过14000种药物-基因的相互作用,涉及2600个基因和6300中靶向这些...
Integration of the drug–gene interaction database (dgidb 4.0) with open crowdsource efforts. Nucleic Acids Res. 2021;49(D1):1144–51. Article Google Scholar Zhou Y, Zhang Y, Lian X, Li F, Wang C, Zhu F, Qiu Y, Chen Y. Therapeutic target database update 2022: facilitating drug ...
The DrugGene Interaction database (DGIdb) was employed to corroborate drug associations with potential therapeutic targets. Additionally, molecular docking (MD) techniques were applied to evaluate the interaction between target protein and four potential AS drugs identified from the ...
4.8. Drug–Gene Interactions To identify potential target drugs for hub genes, we used the Drug–Gene Interaction Database (DGIdb) [52]. DGIdb is an online resource that provides information on drug–gene interactions and druggable genes. These data are compiled from a variety of sources, inclu...
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Drug Gene Interaction Database (DGIdb) web resource43 was used to retrieve FDA-approved drugs that interact with 25 genes including the top ranked nodes of the core network (Table 2) and the identified TFs. We found 10 out of the 25 genes (7 upregulated DEGs and 3 TFs) have 64 intera...
Integration of the Drug-Gene Interaction Database (DGIdb 4.0) with open crowdsource efforts. Nucleic Acids Res. 2021;49(D1):D1144–51. Article CAS PubMed Google Scholar Li X, Lee EJ, Lilja S, Loscalzo J, Schäfer S, Smelik M, et al. A dynamic single cell-based framework for ...
Integration of the Drug-Gene Interaction Database (DGIdb 4.0) with open crowdsource efforts Nucleic Acids Res., 49 (2021), pp. D1144-D1151 CrossrefView in ScopusGoogle Scholar 24 J. Tang, Z.U.R. Tanoli, B. Ravikumar, Z. Alam, A. Rebane, M. Vähä-Koskela, G. Peddinti, A.J...
Details of the Drug Gene Interaction database are reported online Oct. 13 inNature Methods. The database is weighted heavily toward cancer genes but also includes genes involved in Alzheimer's disease, heart disease, diabetes and many other illnesses. The Griffiths created the database with a te...
Databases Utilized by DrugThatGene Here is the list of databases utilied by DTG: -The Drug Gene Interaction Database (DGIdb): Database of drugs with known targets -Cancer Target Discovery and Development (CTD2): Database of drugs with known targets with a focus on cancer targets ...