DGIdb数据库(Drug-Gene Interaction database),是一个药物-基因相互作用数据库,提供了基因与其已知或潜在药物关联信息,目前已经更新到4.0版本。里面的基因主要是癌基因,但是也有一些其他疾病(例如阿尔兹海默病、心脏病、糖尿病等)的相关基因。DGIdb一共有超过14000种药物-基因的相互作用,涉及2600个基因和6300中靶向这些...
As pharmacogenomic (PGx) testing increases in popularity, lay concepts of drug-gene interactions set the stage for shared decision making in precision medicine. Few studies explore what recipients of PGx results think is happening in their bodies when a drug-gene interaction is discovered. To ...
Predicting drug target interaction links Using the multi-relational disease-specific Knowledge Graph (KG) created as explained in “Generating a knowledge graph from biomedical literature” section, we aim to infer probable interactions between drugs and potential targets. Specifically, given a pair of ...
Extraction of Chemical/Drug-Gene interaction DDIs may occur when two or more drugs interact with the same gene8. We hypothesized that information regarding DGIs can enhance the prediction of DDIs as well as ADR types classification by using machine-learning approaches. While databases such as Com...
Of 134 relevant search results, thirteen investigated an interaction. One study reported a significant interaction between NSAID use and the COX1 Pro17Leu polymorphism (P=0.03) whereby the risk reduction associated with NSAID use among homozygous wild-type genotypes was not observed among NSAID users...
A physiologically-based pharmacokinetic/pharmacodynamic modeling approach for drug–drug-gene interaction evaluation of S-warfarin with fluconazole doi:10.1002/psp4.13123Warfarin is a widely used anticoagulant, and its S-enantiomer has higher potency compared to the R-enantiomer. S-warfarin is mainly ...
potential drug-gene interaction (χ2 = 169.2; P < .001) (no drug-gene interaction vs moderate/substantial interaction: odds ratio [OR], 4.32 [95% CI, 3.47 to 5.39]; P < .001) and no/moderate vs substantial interaction: OR, 2.08 [95% CI, 1.52 to 2.84]; P = ...
The annotations of drug-gene interaction terms are publicly available in Drug Gene Interaction (DGIdb v5.0) database at https://www.dgidb.org/. The information on FDA-approved drugs for common psychiatric disorders was extracted from DrugBank 5.1.1, which can be freely downloaded from https://...
展开 关键词: Drug-gene interaction Drug-drug-gene interaction Pharmacogenomics Pharmacogenetic testing Opioid Pain management Polypharmacy DOI: 10.1016/j.apnr.2017.10.001 年份: 2017 收藏 引用 批量引用 报错 分享 全部来源 免费下载 求助全文 Elsevier 国家科技图书文献中心 (权威机构) 掌桥科研 NCBI NCB...
Ch KK, Jamil K, Raju GS (2011) Predicting drug-target interaction in cancers using homology modeled structures of MTHFR gene . Biology and Medicine 3 : 70–81Ch Kalyan K., Kaiser Jamil G.S.Raju (2011) Predicting drug-target interaction in cancers using homology modeled structures of MTHFR ...