Instead, DNA is embedded in a highly complex chromatin structure that controls the location and accessibility of individual genetic regions in a way we are... P Meyer - Springer Netherlands 被引量: 267发表: 2000年 The sperm nucleus: chromatin, RNA, and the nuclear matrix. Within the sperm ...
In many human diseases, such as progeria, cancers, and muscular dystrophies, nuclear morphology becomes severely altered and demonstrates blebbing as a result of impaired nuclear rigidity stemming from disruptions to chromatin compaction and lamina content. To elucidate chromatin's individual role in ...
The eukaryotic nucleus is dynamically organized with respect to particular activities, such as RNA transcription, RNA processing or DNA replication. The sp... B Siemsen,C Reichel,K Leong,... - 《Neuroscience》 被引量: 0发表: 2019年 Spatially confined folding of chromatin in the interphase nucle...
nucleusstructure细胞核functioncellscentrosome 细胞核的结构和功能(Structureandfunctionofnucleus)Thestructureandfunctionof2.1.3nucleusI.knowledgestructureCytoplasmicmatrixMitochondrionChloroplastEndoplasmicreticulumribosomeGolgiapparatusCentrosomevacuoleNuclearmembranenucleolusChromatinThemainfunctionsofthenucleusCellsizeCellwallandcel...
Chromatin is a way for DNA to take up less space in the nucleus of the cell. It also keeps the nucleus organized when the cell divides to form two cells. When DNA is stored as chromatin it is protected, making it safer than if it were left uncoiled in the cell. By keeping the DNA...
The histone H3.3 chaperone HIRA is essential for chromatin assembly in the male pronucleus. In sexually reproducing animals, a crucial step in zygote formation is the decondensation of the fertilizing sperm nucleus into a DNA replication-competent... B Loppin,E Bonnefoy,C Anselme,... - 《Natu...
Cilia, hairlike structures that extend from the surface of many cells, can create movement of surrounding fluid. The nuclear envelope, a double membrane surrounding the nucleus, contains pores that control the movement of substances into and out of the nucleoplasm. Chromatin, a combination of DNA...
Structure meets function: How chromatin organisation conveys functionality Understanding how the genome is compacted in a highly ordered structure that fits in the eukaryotic nucleus, while keeping its capacity of orchestrating the functionality of the cell, is one of the long-standing questions in biol...
Some LncRNAs that are localized to the nucleus or chromatin have been experimentally shown to function in cis to regulate the transcriptional expression of a neighboring gene, or in trans to regulate the transcriptional regulation of a subclass of genes through the interactions between heterogeneous ...
Three-dimensional (3D) chromatin structure is closely related to genome function, in particular transcription. However, the folding path of the chromatin fiber in the interphase nucleus is unknown. Here, we systematically measured the 3D physical distance between pairwise labeled genomic positions in ...