In many human diseases, such as progeria, cancers, and muscular dystrophies, nuclear morphology becomes severely altered and demonstrates blebbing as a result of impaired nuclear rigidity stemming from disruptions to chromatin compaction and lamina content. To elucidate chromatin's individual role in ...
Due to rapid advancement in biochemical and biophysical techniques during the last decade, extensive studies have been undertaken to understand the structure and function of chromatin. Several interesting results have benn reported regarding the changes in basic organization and function of chromatin during...
Recent studies on chromatin structure have elucidated a subunit structure called nucleosome, which consists of 200 base pairs of DNA, two molecules each of the histones H2A, H2B, H3 and H4, and one molecule of histone H1. The nucleosome core contains 140 base pairs of DNA coiled on the sur...
Several levels of eukaryotic chromatin structure havebeen observed: the nucleosome, the 10 nm and 30 nm fibersand loop domains, apparently attached to the nuclearmatrix. In this research, the structure and function ofchromatin at two of these levels was investigated, withstudies on both nucleosome...
In Drosophila embryos, phosphorylated H2A Thr 119 is found in chromatin, but not in the soluble core histone pool. Immunostaining of NHK-1 revealed that... H Aihara,T Nakagawa,K Yasui,... - 《Genes & Development》 被引量: 193发表: 2004年 Preliminary clinical experience with human blastocyst...
A., and J. L. Workman. 1994. Experimental analysis of chromatin function in transcription control. Critical Reviews in Eukaryotic Gene Expression 4:403–441. Paranjape, S. M., R. T. Kamakaka, and J. T. Kadonaga. 1994. Role of chromatin structure in the regulation of transcription by ...
Two meters of DNA is packaged into the nucleus of each eukaryotic cell in the form of chromatin. DNA wraps around a protein histone octamer to form a nucleosome, the fundamental repeating unit of chromatin. The highly basic histone octamer contains two copies each of H2A, H2B, H3 and H4 ...
The organization of chromatin into self-interacting domains is universal among eukaryotic genomes, though how and why they form varies considerably. Here we report a chromosome-scale reference genome assembly of pepper (Capsicum annuum) and explore its 3D organization through integrating high-resolution ...
We find that FACT interacts directly with cohesin, and is dynamically required for its localization on chromatin. Depletion of FACT in metaphase cells prevents cohesin accumulation at pericentric regions and causes reduced binding on chromosome arms. Using the Hi-C technique, we show that cohesin-...
Neutrophil extracellular traps: Is immunity the second function of chromatin? Brinkmann V, Zychlinsky A (2012) Neutrophil extracellular traps: is immunity the second function of chromatin? J Cell Biol 198:773- 783... Brinkmann,Zychlinsky - 《Journal of Cell Biology》 被引量: 0发表: 2012年 Ne...