In many human diseases, such as progeria, cancers, and muscular dystrophies, nuclear morphology becomes severely altered and demonstrates blebbing as a result of impaired nuclear rigidity stemming from disruptions to chromatin compaction and lamina content. To elucidate chromatin's individual role in ...
Hetero-chromatin is a stable yet dynamic structure that varies from one cell to another. It is very tightly packed and has a highly condensed form. Being a repressive structure, it is inhibitory to the expression ofgeneswithin it. Higher order structures are formed by repetitive folding, which ...
Recent studies on chromatin structure have elucidated a subunit structure called nucleosome, which consists of 200 base pairs of DNA, two molecules each of the histones H2A, H2B, H3 and H4, and one molecule of histone H1. The nucleosome core contains 140 base pairs of DNA coiled on the sur...
Chromatin is composed of DNA and histones that are packaged into thin, stringy fibers. These chromatin fibers are not condensed but can exist in either a compact form (heterochromatin) or less compact form (euchromatin). Processes including DNA replication, transcription, and recombination occur in ...
Cancer biology and NuRD: a multifaceted chromatin remodelling complex The nucleosome remodelling and histone deacetylase (NuRD; also known as Mi-2) complex regulates gene expression at the level of chromatin. The NuRD complex... AY Lai,PA Wade - 《Nature Reviews Cancer》 被引量: 439发表: 0年...
Two meters of DNA is packaged into the nucleus of each eukaryotic cell in the form of chromatin. DNA wraps around a protein histone octamer to form a nucleosome, the fundamental repeating unit of chromatin. The highly basic histone octamer contains two copies each of H2A, H2B, H3 and H4 ...
A., and J. L. Workman. 1994. Experimental analysis of chromatin function in transcription control. Critical Reviews in Eukaryotic Gene Expression 4:403–441. Paranjape, S. M., R. T. Kamakaka, and J. T. Kadonaga. 1994. Role of chromatin structure in the regulation of transcription by ...
In Drosophila embryos, phosphorylated H2A Thr 119 is found in chromatin, but not in the soluble core histone pool. Immunostaining of NHK-1 revealed that... H Aihara,T Nakagawa,K Yasui,... - 《Genes & Development》 被引量: 193发表: 2004年 Preliminary clinical experience with human blastocyst...
ChromatinThe Third Edition of Chromatin: Structure and Function brings the reader up-to-date with the remarkable progress in chromatin research over the past three years. It has been extensively rewritten to cover new material on chromatin remodeling, histone modification, nuclear compartmentalization, ...
When nanoparticles can enter a unicellular organis WW Yang,Y Wang,B Huang - 《Environmental Science & Technology Es & T》 被引量: 60发表: 2014年 Chromatin structure in the nuclei of the ciliate Stylonychia mytilus Nucleosome repeat length was studied in three different nuclei of the unicellular...