In situ mapping with Chem-map of small-molecule interactions with DNA and chromatin proteins provides insights that will enhance understanding of genome and chromatin function and therapeutic interventions.Similar content being viewed by others Small molecule targeting of chromatin writers in cancer ...
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We also show that DUET is required for proper microtubule organization during meiosis II, independently of its function in meiosis I. Remarkably, DUET protein shows stage-specific expression, confined to diplotene. We identify two genes TDM1 and JAS with critical functions in cell cycle transitions...
Y Shi,JR Whetstine - 《Molecular Cell》 被引量: 1562发表: 2007年 Role of protein methylation in regulation of transcription. ubiquitylation; combinations of these modifications cooperate to regulate chromatin structure and transcription by stimulating or inhibiting binding of specific ... DY Lee,C Te...
Nuclear architecture and dynamics: chromatin, epigenetics, genomics: Review of Genome Organization and Function in the Cell Nucleus: Edited by Karsten Rippe. on its way to "phase separation" is convincingly presented and optimally illustrated by very segregation and recombina- tion during mitosis and ...
Lyons. Variation in radiation-induced formation of DNA double-strand breaks as a function of chromatin structure. Radiat. Res 130: 309 ... RL Warters,BW Lyons - 《Radiation Research》 被引量: 366发表: 1992年 Radiosensitization of colorectal carcinoma cell lines by histone deacetylase inhibition ...
Chromap also supports wildcards in the read file names and will find all matched read files. To use this function, the read file namesmustbe put in quotation marks: chromap -x index -r ref.fa -1"query*.fq"--SAM -o alignment.sam ...
,... - 《Plant Cell》 被引量: 68发表: 2013年 Aging Hematopoietic Stem Cells Decline in Function and Exhibit Epigenetic Dysregulation regulated expression profile, while the down-regulated profile was marked by genes involved in the preservation of genomic integrity and chromatin remodeling. ... ...
Activating mutations in the tyrosine kinase JAK2 cause myeloproliferative neoplasms, clonal blood stem cell disorders with a propensity for leukaemic transformation. LIF signalling through JAK-STAT enables ES cell self-renewal. Here we show that mouse ES cells carrying the human JAK2V617F mutation coul...
Class I H2Bs, wherein H2Bs with canonical histone-like features are categorized, mainly function in somatic tissues, and show peak expression levels in the actively dividing cells18,19. Class II/III H2Bs are known to control chromatin structure in the reproductive tissues18,20. However, our ...