In situ mapping with Chem-map of small-molecule interactions with DNA and chromatin proteins provides insights that will enhance understanding of genome and chromatin function and therapeutic interventions.Similar content being viewed by others Small molecule targeting of chromatin writers in cancer ...
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The variety of these studies have led to important findings in T cell gene regulation and cell fate determination. Importantly, these findings have also advanced our knowledge of the function of remodeling enzymes in mammalian gene regulation. First we briefly present biochemical and cell-free ...
Association of chromatin with lamin proteins at the nuclear periphery has emerged as a potential mechanism to coordinate cell type-specific gene expression and maintain cellular identity via gene silencing. Unlike many histone modifications and chromatin
Chromatin immunoprecipitation (ChIP) assays begin with covalent stabilization of protein–DNA complexes. Many protein–DNA interactions are transient, and involve multi-protein complexes to orchestrate biological function.In vivocrosslinking coval...
To categorize the function of genes associated with cluster-specific ACRs, we performed Gene Ontology (GO) analyses and found converging terms between scATAC-seq and scRNA-seq for all cell types. For example, genes related to water transport were enriched among mRNAs of cortex cells in scRNA-seq...
We also show that DUET is required for proper microtubule organization during meiosis II, independently of its function in meiosis I. Remarkably, DUET protein shows stage-specific expression, confined to diplotene. We identify two genes TDM1 and JAS with critical functions in cell cycle transitions...
[10], in large part because aside from their packaging function they are also subject to a large number of precisely regulated posttranslational modifications (PTMs) at key residues [11], through which they play a pivotal role in all aspects of chromatin biology (transcription and its ...
Activating mutations in the tyrosine kinase JAK2 cause myeloproliferative neoplasms, clonal blood stem cell disorders with a propensity for leukaemic transformation. LIF signalling through JAK-STAT enables ES cell self-renewal. Here we show that mouse ES cells carrying the human JAK2V617F mutation coul...
,... - 《Plant Cell》 被引量: 68发表: 2013年 Aging Hematopoietic Stem Cells Decline in Function and Exhibit Epigenetic Dysregulation regulated expression profile, while the down-regulated profile was marked by genes involved in the preservation of genomic integrity and chromatin remodeling. ... ...