Eu-chromatin Eu-chromatin consists of structures that are loosely packed. Modification to the histone tails allows them to be more open. This enables the easy access of DNA within these structures. It’s main function is the initiation of transcription. Eu-chromatin is actively involved in thetr...
This simple definition does not consider the degree of proximity required to be functionally meaningful nor does it speak to the length of the intervening sequence, i.e. the size of the loop. Looped structures have been detected at numerous gene loci in a fashion that juxtaposes important ...
Many mitochondria-encoded RNAs are also modified in the mitochondria by nuclear-encoded enzymes, which also function in the nucleus. Many other epigenetic enzymes that have well-characterised nuclear chromatin functions are also found in the mitochondria. A schematic overview of the principles of commun...
The relationships between chromosomal compartmentalization, chromatin state and function are poorly understood. Here by profiling long-range contact frequencies in HCT116 colon cancer cells, we distinguish three silent chromatin states, comprising two ty
They can also function to disrupt an interaction between the histone and a chromatin factor. For instance, H3K4me3 can prevent the NuRD complex from binding to the H3 N-terminal tail [79, 80]. This simple mecha- nism seems to make sense because NuRD is a general transcriptional repressor ...
A simple model for the function of regulatory elements. Spheres A, B and C represent factories rich in different sets of transcription factors and associated halos indicate the probability that promoter 1, 2 or 3 will collide with a factory (red indicates high probability). The low-probability ...
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We asked whether deletion of chromatin (or transcription) regulators will decrease expression diver- gence, as expected if the regulators function as generators of variability, or, conversely, will increase expression divergence, as expected if the regulators function primarily as c...
categories was performed by ChIPseeker annotatePeak function, which reports the genomic region of the peak (following the priority order: Promoter, 5′ UTR, 3′ UTR, Exon, Intron, Downstream, and Intergenic), the position and strand of the nearest gene, and the distance to TSS of the ...
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