Chromatin modifiers target vascular smooth muscle cell function and vascular shear stress to expedite disease development. As evidenced by previous studies, HDAC3, 5, and 7 have been identified as being responsible for promoting oscillatory shear stress in atherosclerotic endothelial cells and inhibiting ...
BET inhibitors, such as JQ1, function by competitively binding to acetylated histone lysine residues to prevent interactions between BET proteins and chromatin. Although these drugs have gained notable attention as anti-tumor agents in the treatment of certain cancers37,38,39,40, as well as with ...
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但是,在人类基因组中编码的1,600多种转录因子中,只有一小部分被检测了。 这篇文章作为ENCODE项目的一部分,使用人类使用人类Hepg2细胞系中的208个染色质相关蛋白质(CAP)进行高通量测序,然后对得到的染色质免疫沉淀数据进行处理和分析。本文旨在尽可能完整的概述这种细胞类型的基因调控网络。 二、数据来源 ...
However, the function of RNAi components in animal cell chromatin organization-mediated transcriptional regulation remains unclear. We previously reported that in Drosophila, RNAi components (dAgo2 and Dicer) are preferentially associated with active chromatin and affect transcription by regulating RNA pol ...
Transcription factor neuromancer/TBX20 is required for cardiac function in Drosophila with implications for human heart disease. Proc Natl Acad Sci U S A. 2008;105:19833–8. Article CAS Google Scholar Gogstad GO, Hagen I, Korsmo R, Solum NO. Characterization of the proteins of isolated ...
先前的研究表明,非编码风险变异富集于疾病相关细胞类型中活跃的cCREs中。利用新注释的细胞类型解析人脑cCREs,作者预测了与不同神经精神疾病相关的细胞类型。进行了连锁不平衡评分回归(LDSC)分析,确定与神经精神疾病相关的DNA变异的遗传遗传性是否在cCREs中显着富集。发现19种精神疾病和特征与作者鉴定的一种或多种细胞...
To test the function of the conserved CTCF motif in host-integrated HPV16, we performed ATAC-seq, CTCF ChIP-seq, and RNA-seq on 5 HPV16+ cell lines: 93-VU147T [28] (7 integration sites), CaSki [29] (6 integration sites), HMS-001 [30] (1 integration site), SCC-090 [31] (1 ...
Chromatin structure plays a key role in regulating gene expression by allowing DNA accessibility to transcriptional machinery and transcription factors. The packaging of DNA into nucleosomes forms a closed structure that is not highly accessible to transcriptional elements whereas the open nucleosome structu...
(ETH Zurich) sought to understand a significant challenge to maintaining weight loss – the retention of an “obesogenic” memory – via single-cell transcriptomic/epigenetic analyses in human/mouse adipose tissues before and during obesity and after weight loss. Their findings – that adipose tissue...