RNA-binding proteins (RBPs) play an essential role in regulating the function of RNAs in a cellular context, but our ability to control RBP activity in time and space is limited. Here, we describe the engineering of LicV, a photoswitchable RBP that binds
T. Sequence-specific antirepression of histone H1-mediated inhibition of basal RNA polymerase II transcription. Science 251, 643–649 (1991). Article CAS PubMed Google Scholar Cirillo, L. A. & Zaret, K. S. An early developmental transcription factor complex that is more stable on nucleosome...
RNA-binding proteins (RBPs) play an essential role in regulating the function of RNAs in a cellular context, but our ability to control RBP activity in time and space is limited. Here, we describe the engineering of LicV, a photoswitchable RBP that binds to a specific RNA sequence in resp...
摘要: The versatility of RNA structure and function. Jacques Monod Conference: New insights into the mechanism of mRNA translation: the significance of RNA structure, Aussois, France, 22-26 March 1999. - ResearchGateDOI: 10.1016/S0168-9525(99)01779-5 ...
In this essay, we investigate the evidence whether persistent infection with RNA viruses could be a major factor that affects the response to exogenous dsRNA in insects. The occurrence of RNA viruses in different insect groups will be discussed, as well as several mechanisms by which viruses ...
It is now clear that there is a diversity of circular RNAs in biological systems. Circular RNAs can be produced by the direct ligation of 5' and 3' ends of linear RNAs, as intermediates in RNA processing reactions, or by "backsplicing," wherein a downstream 5' splice site (splice donor...
"One has to decouple the transcript from the DNA," Paralkar said. "Future studies of lncRNA function should adhere to that requirement." He added that the discovery of this enhancer function for one example of a lncRNA gene points to the possibility that this is a broadly used mechanism ...
Characterization of nuclear polyadenylated RNA-binding proteins in Saccharomyces cerevisiae. (1998). Intron function in the nonsense-mediated decay of the -globin mRNA: indications that pre-mRNA splicing in the nucleus can influence mRNA ... Wilson,M S. - 《Journal of Cell Biology》 被引量...
Guanine-rich sequences are able to form complex RNA structures termed RNA G-quadruplexes in vitro. Because of their high stability, RNA G-quadruplexes are proposed to exist in vivo and are suggested to be associated with important biological relevance. H
(RNP). A complex of proteins and RNA. A-form helix A right-handed (clockwise) helix in which base pairs are significantly tilted with respect to the central axis of the helix. The grooves are not as well defined as in the B-form helix. RNA commonly adopts an A-form helical configurati...