RNA-binding proteins (RBPs) play an essential role in regulating the function of RNAs in a cellular context, but our ability to control RBP activity in time and space is limited. Here, we describe the engineering of LicV, a photoswitchable RBP that binds
Binding of DNA and of RNA are no longer considered functionally distinct, partly owing to the discovery that DNA- and RNA-binding proteins (DRBPs) can bind long non-coding RNAs and DNA. The unique functional characteristics of DRBPs stem from their speci
Fast hash function for DNA/RNA sequences. Contribute to bcgsc/ntHash development by creating an account on GitHub.
select article Isoform balance of the long noncoding RNA NEAT1 is regulated by the RNA-binding protein QKI, governs the glioma transcriptome, and impacts cell migration Research articleOpen access Isoform balance of the long noncoding RNA NEAT1 is regulated by the RNA-binding protein QKI, ...
The identification of G4 associated proteins has mostly relied on affinity proteomics experiments employing RNA and DNA G4 oligomers as baits to isolate G4 interactors from cellular extracts 62, 63, 64, 65. Other approaches involve computational analysis of genomic protein binding sites to assess ...
These two gene-silencing pathways are discussed in terms of kinetic models and the structural basis of the underlying mechanisms. The major determinant of small RNAs that functions as specific triggers of gene silencing is the A-form helical geometry of RNA. The A-form helix and high-resolution...
Guanine-rich sequences are able to form complex RNA structures termed RNA G-quadruplexes in vitro. Because of their high stability, RNA G-quadruplexes are proposed to exist in vivo and are suggested to be associated with important biological relevance. H
The vast majority of RNAs produced by RNA polymerase II are mRNAs, and as such are capped and polyadenylated for subsequent transport outside of the nucleus, yet a surprising amount of RNA remains in the nucleus, where the bulk of RNA turnover occurs. These nuclear residents are incredibly ...
我们在标题中搜索了关键词“complex”,然后删除了所有分辨率低于2.5Å,与RNA或DNA形成复合物,是理论模型,包含与蛋白质共价结合的配体,或是肽抑制剂的条目。这产生了1269个条目。我们仅保留了那些具有相同PDB条目四个字母识别代码的第二个和第三个字母的第一个条目,因为它们包含相似的蛋白质结构。这产生了697个条目...
MicroRNAs (miRNAs) are small non-coding RNA transcripts that affect various cellular pathways by serving as regulators of gene expression at the translational and transcriptional level. Nuclear receptors (NRs) are ligand-activated transcription factors t