Hence, these challenges that impact and potentially limit the effectiveness of TTI need to be incorporated together into one model of COVID-19 control, namely (1) the existence of asymptomatic, yet infectious carriers14,15—which are a challenge for symptom-driven but not for random-testing stra...
Investigating the fates of trigger RNAs and target transcripts in RNA-mediated interferenceParrish, SNParrish, SNFire, AZFire, AZ
PD-1/PD-L1 has been shown to be specifically expressed on different cell types in TME [7], therefore investigating the role of PD-1/PD-L1 is helpful for the diagnosis and treatment of glioma patients. Expression, distribution and regulation of PD-L1 in glioma microenvironment Expression and ...
Tumor gene expression is predictive of patient prognosis in some cancers. However, RNA-seq and whole genome sequencing data contain not only reads from host tumor and normal tissue, but also reads from the tumor microbiome, which can be used to infer the
Effective RNA interference (RNAi) methods have been developed in many pest species, enabling exploration of gene function. Until now RNAi had not been attempted in the cat flea, Ctenocephalides felis, although the development of RNAi approaches would open up potential avenues for control of this...
While these experiments focus on investigating modifications in mRNAs, the approaches we discuss can also be applied to studying other aspects of translation.Access through your organization Check access to the full text by signing in through your organization. Access through your organization ...
RNA cis-elements - Yes (Rfam & ERPIN) similar functional RNAs - Yes (BLAST+fRNAdb) ncRNA hybridization region - Yes (BLAST+RNAcofold+NONCODE) Open reading frame - Yes (RegRNA 2.0) Motif region structure - Yes (RNAfold) RNALogo displaying - Yes (RNALogo) GC-content Ratio - Yes (RegRN...
Here we discuss the current status, the challenges and prospects regarding the clinical applications of CAR-T, CAR-NK, and CAR-M cells in the management of patients with solid tumors. We also highlight the potential advantages of CAR-NK and CAR-M cells over CAR-T cells. ...
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1). Here, we use the biological model system of macrophage activation as a framework to demonstrate how we approach the study of lncRNA biology. We provide a step-by-step guide to consider when studying lncRNAs. Furthermore, we discuss the challenges, as well as the emergence of new ...