RNA-binding proteins are central to this form of regulation. They act as effectors of RNA stability and translation efficiency, they guide transcripts to defined locations within a cell, they control the fidelity of gene decoding, and they function as cofactors to promote the activity of ...
RNA-binding proteins (RBPs) play an essential role in regulating the function of RNAs in a cellular context, but our ability to control RBP activity in time and space is limited. Here, we describe the engineering of LicV, a photoswitchable RBP that binds to a specific RNA sequence in resp...
Regulation of beta-cell function by RNA-binding proteins. Molecular Metabolism, 2013, 2(4): 348-355Magro MG & Solimena M 2013 Regulation of β-cell function by RNA-binding proteins. Molecular Metabolism 2 348-355. (doi:10.1016/j.molmet.2013.09.003)...
Here, we review the literature to date on the structure and function of these chloroplast RNA-binding proteins. For example, the functional protein domains involved in RNA binding, such as the RNA-recognition motifs, the chloroplast RNA-splicing and ribosome maturation domains, and the ...
(CSD). A small (∼70 kDa) domain with high similarity to the ribonucleoprotein 1 RNA-binding motif. This domain is found in DNA- and RNA-binding proteins in bacteria, archaea and eukaryotes. Interfaces The solvent-accessible portions of a protein that are capable of binding a ligand — in...
RNA, they too found more than they expected: 300 proteins previously unknown to bind to RNA - more than half as many as were already known to do so. The study, published online in Cell, could help to explain the role of genes that have been linked t...
RNA-binding proteins siRNAs Transcription factors Introduction Highly conserved histone proteins undergo several types of covalent modifications including acetylation, methylation, phosphorylation, ubiquitylation, SUMOylation, citrullination and ADP-ribosylation [1]. These modifications that are deposited and remove...
The regulatory function of DNA-binding proteins is that they determine when a gene is switched on or off. DNA-binding proteins are proteins that...Become a member and unlock all Study Answers Start today. Try it now Create an account Ask a question Our experts can answer your tough ...
Guanine-rich sequences are able to form complex RNA structures termed RNA G-quadruplexes in vitro. Because of their high stability, RNA G-quadruplexes are proposed to exist in vivo and are suggested to be associated with important biological relevance. H
Perhaps the most striking example of RNA structure being critical to an essential cellular process is the ribonucleoprotein complex that constitutes the translational machinery. Ribosomal RNA (rRNA) molecules act as a scaffold on which proteins are assembled to form ...