RNA-binding proteins (RBPs) play an essential role in regulating the function of RNAs in a cellular context, but our ability to control RBP activity in time and space is limited. Here, we describe the engineering of LicV, a photoswitchable RBP that binds to a specific RNA sequence in resp...
RNA-binding proteins are central to this form of regulation. They act as effectors of RNA stability and translation efficiency, they guide transcripts to defined locations within a cell, they control the fidelity of gene decoding, and they function as cofactors to promote the activity of ...
(2013) Regulation of β-cell function by RNA-binding proteins. Molecular Metabolism 2 , 348-355 Online publication date: 1-Nov-2013. /Magro MG & Solimena M 2013 Regulation of β-cell function by RNA-binding proteins. Molecular Metabolism 2 348-355. (doi:10.1016/j.molmet.2013.09.003)...
RNARNA‐binding proteinRNA modificationRNA motifRNA structureRNA–protein interactionsAlmost all RNAs need to interact with proteins to fully exert their functions, and proteins also bind to RNAs to act as regulators. It has now become clear that RNA–protein interactions play important roles in ...
RNA-Binding ProteinsCatalytic DomainNucleic Acid ConformationProtein ConformationDimerizationModels, MolecularEnzyme ActivationMany RNA-binding proteins have modular structures and are composed of multiple repeats of just a few basic domains that are arranged in various ways to satisfy their diverse functional...
Here, we review the literature to date on the structure and function of these chloroplast RNA-binding proteins. For example, the functional protein domains involved in RNA binding, such as the RNA-recognition motifs, the chloroplast RNA-splicing and ribosome maturation domains, and the ...
RNA, they too found more than they expected: 300 proteins previously unknown to bind to RNA - more than half as many as were already known to do so. The study, published online in Cell, could help to explain the role of genes that have been linked t...
The Set1 family of histone H3 lysine 4 (H3K4) methyltransferases is highly conserved from yeast to human. Here we show that the Set1 complex (Set1C) directly binds RNA in vitro through the regions that comprise the double RNA recognition motifs (dRRM) an
The regulatory function of DNA-binding proteins is that they determine when a gene is switched on or off. DNA-binding proteins are proteins that...Become a member and unlock all Study Answers Start today. Try it now Create an account Ask a question Our experts can answer your tough ...
Guanine-rich sequences are able to form complex RNA structures termed RNA G-quadruplexes in vitro. Because of their high stability, RNA G-quadruplexes are proposed to exist in vivo and are suggested to be associated with important biological relevance. H