Serum free light chain analysis accelerates the detection of treatment response because the free light chains have a much shorter half-life (3-5 hours) than intact immunoglobulins (about 21 days). Although it is traditionally used for light chain-only plasma cell disorders, the test is also use...
Monoclonal κ and λ immunoglobulin free light chains (FLC) in the urine are important biomarkers for the diagnosis and monitoring of a number of plasma cell dyscrasias including multiple myeloma. To date, laboratory FLC tests provide the only means of quantitating FLC and often ...
How lab staff and the estimation of free light chains can combine to aid the diagnosis of light chain disease. 来自 Semantic Scholar 喜欢 0 阅读量: 20 作者: DAVID SINCLAIR,LAURA WAINWRIGHT 摘要: The diagnosis and monitoring of free light chain abnormalities and disease has always been a ...
Related to light chain:Myosin light chain kinase n. Either of the two smaller polypeptide chains in an immunoglobulin molecule, consisting of an antigen-binding portion with a variable amino acid sequence and a constant region that occurs in two different forms in humans. ...
Free Light Chains (FLCs) are immunoglobulin light chains which are circulating in serum in a free state (unbound). There are two types of immunoglobulin light chain produced in humans, designated kappa (κ) and lambda (λ). The quantification of serum FLC is used as an aid in the diagnosi...
Serum free light chains: an alternative to the urine Bence Jones proteins screening test for monoclonal gammopathies. Clin Chem. 2006;52(9):1743–8. Article CAS PubMed Google Scholar Dispenzieri A, Kyle R, Merlini G, Miguel JS, Ludwig H, Hajek R, et al. International Myeloma Working ...
Development of a highly-sensitive multi-plex assay using monoclonal antibodies for the simultaneous measurement of kappa and lambda immunoglobulin free light chains in serum and urine. J Immunol Methods. 2013;391(1–2):1–13. Article PubMed CAS Google Scholar Download references...
Objectives Testing of serum-free light chains kappa (κ) and lambda (λ), along with ratio (FLCR) is essential for the diagnosis and management of monoclonal gammopathies. Accurate clinical diagnosis depends upon appropriate local population reference in
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Urine Protein Immunofixation Electrophoresis: Free Light Chain Urine Immunofixation Electrophoresis Is More Sensitive than Conventional Assays for Detecting Monoclonal Light Chains and Could Serve as a Marker of Minimal Residual Disease 2023, Lab Medicine Kappa Free Light Chain Drift Prompts the Need for...