light chain Thesaurus Medical Financial Encyclopedia Wikipedia Related to light chain:Myosin light chain kinase n. Either of the two smaller polypeptide chains in an immunoglobulin molecule, consisting of an antigen-binding portion with a variable amino acid sequence and a constant region that occurs ...
The diagnosis and monitoring of free light chain abnormalities and disease has always been a challenging area for laboratory and clinical staff because urine electrophoresis is often overlooked in the investigations requested. We present here three case reports which illustrate first, the role of the ...
Concentrations of Serum Free Light Chains in Kappa and Lambda Lesions in Light-Chain Myelomasdoi:10.1093/labmed/lmy067Gurmukh SinghOxford Academic
Free Light Chains (FLCs) are immunoglobulin light chains which are circulating in serum in a free state (unbound). There are two types of immunoglobulin light chain produced in humans, designated kappa (κ) and lambda (λ). The quantification of serum FLC is used as an aid in the diagnosi...
Immunochemical quantification of free immunoglobulin light chains from an analytical perspective. Clin Chem Lab Med. 2006;44(5):522–32. Article CAS PubMed Google Scholar Pretorius CJ, Klingberg S, Tate J, Wilgen U, Ungerer JP. Evaluation of the N Latex FLC free light chain assay on the...
Also Known As: Free Light Chains, SFLC, FLC, Kappa and Lambda Free Light Chains, Quantitative Serum Free Light Chains with Ratio Board Approved At a Glance Why Get Tested? To help detect, diagnose, and monitor plasma cell disorders (dyscrasias) such as multiple myeloma, primary amyloidosis,...
Free light chains were isolated from the urine of both normal individuals and patients with tubular proteinuria by means of ultrafiltration, zone electrophoresis, gel chromatography, and ion exchange chromatography. The yield of purified chains from each liter of pooled normal urine was, on the ...
Urine Protein Immunofixation Electrophoresis: Free Light Chain Urine Immunofixation Electrophoresis Is More Sensitive than Conventional Assays for Detecting Monoclonal Light Chains and Could Serve as a Marker of Minimal Residual Disease 2023, Lab Medicine Kappa Free Light Chain Drift Prompts the Need for...
22.Myatt EA, Westholm FA, Weiss DT, Solomon A, Schiffer M, Stevens FJ. Pathogenic potential of human monoclonal immunoglobulin light chains: relationship of in vitro aggregation to in vivo organ deposition. Proc Natl Acad Sci USA 1994;91:3034–8.10.1073/pnas.91.8.3034Search in Google Scholar...
P Milani,G Palladini,G Merlini - 《Scand J Clin Lab Invest Suppl》 被引量: 19发表: 2016年 Quantitation of serum free light chains does not compensate for serum immunofixation only when screening for monoclonal gammopathies. Detection of plasma cell dyscrasias (PCD) requires screening of serum...