Serum free light chain analysis accelerates the detection of treatment response because the free light chains have a much shorter half-life (3-5 hours) than intact immunoglobulins (about 21 days). Although it is traditionally used for light chain-only plasma cell disorders, the test is also use...
Background: Serum free light chains detection assays are consistently meeting greater interest for the diagnosis and monitoring of monoclonal gammopathies and plasma cell dyscrasias. Nowadays, there are neither standardized methods nor reference material for the determination of free light chains; for ...
Serum free light chains: an alternative to the urine Bence Jones proteins screening test for monoclonal gammopathies. Clin Chem. 2006;52(9):1743–8. Article CAS PubMed Google Scholar Dispenzieri A, Kyle R, Merlini G, Miguel JS, Ludwig H, Hajek R, et al. International Myeloma Working ...
Ressources | Current Status of Detecting Monoclonal Antibodies and Free Light Chains in Serum | Deutschland
Immunoglobulin free light chains (FLCs) are normally produced by B cells in slight excess to provide the correct assembly of intact immunoglobulins. However, only 60% of FLCs assemble correctly into newly synthesized immunoglobulins, while the rest are released into the bloodstream giving rise to ...
The free light chain (FLC) assay does quantify concentrations of free kappa and lambda immunoglobulin light chains in serum. The potential use of this diagnostic test for patients diagnosed with plasma cell dyscrasias includes, amongst others, primary diagnosis, prognosis, detection of relapse and mon...
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Early reduction of serum-free light chains associates with renal recovery in myeloma kidney. J Am Soc Nephrol. 2011;22(6):1129–36. Article PubMed PubMed Central CAS Google Scholar Jain P, Calvert M, Cockwell P, McManus RJ. The need for improved identification and accurate classification ...
The objective was to explore the relationship between the levels of serum and urinary free light chains (FLCs) during the progression of renal damage in multiple myeloma (MM) patients. We examined 91 cases of MM patients, detected levels of serum FLCs (sFLCs), urinary FLCs (uFLCs), and ...
Quantification of Free Immunoglobulin Light Chains in Urine. J. Appl. Lab. Med. 2023, 8, 1101–1114. [Google Scholar] [CrossRef] [PubMed] Brebner, J.A.; Stockley, R.A. Polyclonal free light chains: A biomarker of inflammatory disease or treatment target? F1000 Med. Rep. 2013, 5, 4...