Biochemical tests for the presence of free light chains (FLCs) are used to indicate a possible diagnosis of multiple myeloma (MM). Most guidelines recommend measurement of urinary FLCs; however, recent research indicates that the presence of FLCs in blood might be a better indicator....
This test measures the amount of free kappa and lambda light chains in the blood and calculates a kappa/lambda ratio to help detect, diagnose, and monitor conditions associated with an increased production of free light chains. Each type of immunoglobulin is composed of four protein chains: two...
Ressources | Current Status of Detecting Monoclonal Antibodies and Free Light Chains in Serum | Deutschland
Levels of κ and λ serum free light chains and the κ/λ ratio were not different among IgG4-related disease (n = 45), Sjögren’s syndrome (n = 25) and sarcoidosis (n = 15) patients (median with interquantile range). Statistics performed by Kruskal–Wallis test. sFLC...
- 《Blood》 被引量: 78发表: 2007年 Serum Free Light Chains in the Diagnosis and Monitoring of Patients with Plasma Cell Dyscrasias Serum free light chain assay is a recently available test for diagnosis and monitoring of patients with plasma cell dyscrasias. In particular, this test is ...
Effects of paraprotein heavy and light chain types and free light chain load on survival in myeloma: an analysis of patients receiving conventional-dose chemotherapy in Medical Research Council UK multiple myeloma trials. Blood. 2006;108(6):2013–9. Article PubMed CAS Google Scholar te Velthuis...
When an innocent young woman is found drained of her blood in movie theater, the police dub this dangerous new killer “Dracula.” The victim’s friend appears to be the main suspect, but when the twins dig further, the case takes an unexpected turn! Can you help Eleanor and Randall get...
Objectives Testing of serum-free light chains kappa (κ) and lambda (λ), along with ratio (FLCR) is essential for the diagnosis and management of monoclonal gammopathies. Accurate clinical diagnosis depends upon appropriate local population reference in
Immunoglobulin free light chains and solitary plasmacytoma of bone Blood, 108 (2006), pp. 1979-1983 View PDFView articleCrossrefView in ScopusGoogle Scholar 11 A Dispenzieri, RA Kyle, JA Katzmann, et al. Immunoglobulin free light chain ratio is an independent risk factor for progression of sm...
2023, Journal of Applied Laboratory Medicine In response to: Defining new reference intervals for serum free light chains in individuals with chronic kidney disease: results of the iStopMM study 2022, Blood Cancer Journal View all citing articles on ScopusView...