Free light chains (FLC) or serum free light chains (SFLC) refer to those that are not part of whole (intact) immunoglobulins and are present in the blood. This test measures the amount of free kappa and lambda light chains in the blood and calculates a kappa/lambda ratio to help detect...
Biochemical tests for the presence of free light chains (FLCs) are used to indicate a possible diagnosis of multiple myeloma (MM). Most guidelines recommend measurement of urinary FLCs; however, recent research indicates that the presence of FLCs in blood might be a better indicator....
Structure of human blood coagulation factor Ⅷ (FⅧ) in relation to its activation process was investigated. FⅧ was purified from a commercial FⅧ concentrate by immunoaffinity chromatography and its dissociated subunits, heavy and light chains were isolated. The light chain (FⅧ-L) was treated...
- 《Blood》 被引量: 78发表: 2007年 Serum Free Light Chains in the Diagnosis and Monitoring of Patients with Plasma Cell Dyscrasias Serum free light chain assay is a recently available test for diagnosis and monitoring of patients with plasma cell dyscrasias. In particular, this test is ...
2023, Journal of Applied Laboratory Medicine In response to: Defining new reference intervals for serum free light chains in individuals with chronic kidney disease: results of the iStopMM study 2022, Blood Cancer Journal View all citing articles on ScopusView...
(A) Levels of κ serum free light chains and the κ/λ ratio were different between active (n = 25) compare to inactive (n = 20) IgG4-related disease patients (median with interquantile range). Statistics performed by Mann–Whitney U test. (B) The receiver operating characterist...
Blood cancer journal. 2011;1(9):e35. Article PubMed PubMed Central CAS Google Scholar Song X, Cong Z, Wilson K. Real-world treatment patterns, comorbidities, and disease-related complications in patients with multiple myeloma in the United States. Curr Med Res Opin. 2016;32(1):95–103....
Myo-II molecules are hexameric enzymes consisting of two heavy chains, two regulatory light chains (MRLC) and two essential light chains3. Myo-II activity is regulated by dynamic phosphorylation and dephosphorylation of the MRLC4. Phosphorylation of MRLC by several kinases brings the myosin complex ...
Absolute values of immunoglobulin free light chains are prognostic in patients with primary systemic amyloidosis undergoing peripheral blood stem cell transplantation. Blood. 2006;107(8):3378–83. Article PubMed Central CAS PubMed Google Scholar Dingli D, Kyle RA, Rajkumar SV, Nowakowski GS, ...
Hadzidimitriou, A. et al. Evidence for the significant role of immunoglobulin light chains in antigen recognition and selection in chronic lymphocytic leukemia.Blood113, 403–411 (2009). ArticleCASPubMedGoogle Scholar Shah, H. B. et al. HumanC. difficiletoxin-specific memory B cell repertoires ...