This collateral effect was suppressed in C/EBP (CCAAT‐enhancer‐binding protein)‐homologous protein (CHOP)‐deficient mouse embryonic fibroblasts or DR5 knockdown HCT116 cells, but not in p53‐deficient HCT116 cells. The results from in vitro studies suggest the involvement of the p53‐...
Though this may be expected as there was no major effect previously seen with TRi-1 or TRi-2 treatment on GPX4 thermostability [21]. The findings thereby suggest that the FINs could specifically modulate GPX4 integrity in a manner not seen with the TRi compounds, although all compounds in ...
3.3. NAC alleviates the inhibitory effect of gigantol on lung cancer cells To further validate that gigantol induces ferroptosis in lung cancer cells via the SLC7A11-GPX4 axis, we used N-acetylcysteine (NAC), a precursor for cysteine and GSH biosynthesis. Our results demonstrated that NAC signifi...
The LDL receptor related protein 8 (LRP8) regulates selenium levels and thereby ferroptosis in cancer cells [41]. There is no known involvement of SAL or MUC1-C in LRP8 regulation. We found that SAL treatment of DU-145 and H660 cells decreases LRP8 expression (Fig.4A; Supplementary Fig....
Berberine (BBR) has been explored as a potential anti-liver fibrosis agent, but the underlying mechanisms are unknown. In the current study, we aimed to investigate the molecular mechanisms underlying the effect of BBR against liver fibrogenesis in thioa
Effect of sterigmatocystin or aflatoxin contaminated feed on lipid peroxidation and glutathione redox system and expression of glutathione redox system regulatory genes in broiler chicken. Antioxid (Basel). 2019;8(7):201. Article CAS Google Scholar Li X, Feng C, Sha H, Zhou T, Zou G, Liang...
E, H Immunohistochemistry staining observed the effect of PZH on GPX4 expression in the liver tissues of different groups, orange color is positive expression. F, I Western blot assay detected the effects of PZH on SLC7A11 protein expression in the liver tissues of different groups. Data are ...
Tumors Cite this article: Pan H, Chen X, Xiao M, et al.Multifunctional RGD coated a single-atom iron nanozyme: A highly selective approach to inducing ferroptosis and enhancing immunotherapy for pancreatic cancer.Nano Research,2024, 17(6): 5469-5478.https://doi.org/10.1007/s12274-024-6492-...
1B). Notably, 2 mM melatonin significantly increased the cellular ROS level, while 0.2 mM melatonin did not yield any significant effect. In addition, higher ROS levels were produced with the combined use of 2 mM melatonin and 5 μM erastin. Melatonin combined with erastin decreased cell ...
The rat model was used to examine the effect of TMBPA on the function of Leydig cells during the late puberty from PND35 to PND56 (Fig. 1A), during which immature cells mature into adult Leydig cells (Ye et al., 2017). The body weight, testis weight, and epididymal weight of rats ...