killing in KRAS-mutant cancer cells.174Mutant KRAS can also elevate FSP1 by activating MAPK and NRF2 pathways to protect KRAS-mutant cells from ferroptosis during tumor initiation.202Combining FSP1 in ferroptosis-inducing therapy represents an effective strategy for treating KRAS-mutant tumors.202Moreo...
Cucurbitacin B (CuB) is a widely available triterpenoid molecule that exhibits various biological activities. Previous studies on the anti-tumour mechanism of CuB have mostly focused on cell apoptosis, and research on the ferroptosis-inducing effect has rarely been reported. Herein, we first ...
Cancer typeCompoundTargetEffectReferences Osteosarcoma PEITC Consuming GSH Inducing ferroptosis [30], [40] Nanomedicine Accumulating Fe2+ ; consuming GSH Inducing ferroptosis [29] Tirapazamine Suppressing SLC7A11 Inducing ferroptosis [70] EF24 Accumulating ROS Inducing ferroptosis [25] KDM4A Accelerating sys...
Finally, we provide an outlook on therapeutic strategies based on Nrf2 inhibition combined with ferroptosis inducing drugs.AntioxidantsBaiskhanova, DinaraSchfer, Heiner
(Tim-AIII), a steroidal saponin fromAnemarrhena Asphodeloides Bunge, induces NSCLC cell death and G2/M arrest. It achieves this therapeutic effect by interacting with its target protein HSP90, facilitating the ubiquitination and subsequent degradation of GPX4, thereby inducing ferroptosis [83]. Zer...
Schizandrin A can inhibit non-small cell lung cancer cell proliferation by inducing cell cycle arrest, apoptosis and autophagy. Int J Mol Med 2021;48:214. https://doi.org/10.3892/ijmm.2021.5047.Search in Google Scholar PubMed PubMed Central 10. Fu, K, Zhou, H, Wang, C, Gong, L, ...
When iron overload occurs, excess iron is stored in ferritin, and free iron participates in inducing ROS generation through the Fenton reaction. Cellular antioxidant systems eliminating lipid peroxidation of membrane phospholipids mainly function through the system Xc-/GPX4 axis (B) and other parallel...
There is also some evidence that iron levels may be dynamically regulated within the cell in response to ferroptosis-inducing conditions, suggesting that uncharacterized regulatory mechanisms may alter intracellular iron, possibly in an attempt to negatively regulate the onset of ferroptosis (Ma et al....
Ferroptosis promotes anti-tumor immune response by inducing immunogenic exposure in HNSCC We found that the occurrence of ferroptosis had significantly reduced the number of myeloid-derived suppressor cells (MDSCs) and tumor-associated M2-like ... YY Zhao,JX Lian,Z Lan,... - 《Oral Diseases》 ...
immune responses and exacerbated HSV-1 replication in vivo, suggesting a destructive effect of lipid peroxidation in the innate immune response [112]. Hence, whether ferroptosis promotes or inhibits the cGAS-STING signaling pathway depends on the disease states, which should be further studied....