Ferroptosis related gene signature in T cell-mediated rejection after kidney transplantationTCMRFerroptosisKidney transplantationAllograft rejectionMedical bioinformaticsT cell-mediated rejection is an important factor affecting early transplant kidney survival. Ferroptosis has been shown to play a pathogenic role...
The workflow for identifying ferroptosis-associated genes and constructing signature is delineated in Fig.1a. We collected ferroptosis-related genes from ferroptosis database (FerroDb)14, while gene expression matrix and clinical traits of EGFRWTLUAD patients were extracted from The Cancer Genome Atlas ...
Moreover, we established gene modules related to TMB according to weighted gene coexpression network analysis (WGCNA) and explored the functions of these modules in AML and their relationships with TMB. We focused on the top 30 most frequent genes through a detailed survey of missense mutations ...
In conclusion, a novel ferroptosis-related gene signature can be used for prognostic prediction in HCC. Targeting ferroptosis may be a therapeutic alternative for HCC. Keywords: hepatocellular carcinoma, ferroptosis, gene signature, overall survival, immune status ...
A ferroptosis-related gene signature for overall survival prediction and immune infiltration in lung squamous cell carcinoma. Biosci Rep. 2022;42:BSR20212835. Article CAS PubMed PubMed Central Google Scholar Liu J, Ma H, Meng L, Liu X, Lv Z, Zhang Y, et al. Construction and external ...
The functions of key target genes were related to oxidative phosphorylation, focal adhesion, and ECM-receptor interaction. A The KEGG significant enrichment pathway for the EGFR single gene. B The KEGG significant enrichment pathway for the SRC single gene. C The KEGG significant enrichment pathway ...
Construction of a Novel Ferroptosis-Related Gene Signature of Atherosclerosis. Front Cell Dev Biol. 2021;9:800833. https://doi.org/10.3389/fcell.2021.800833. Article PubMed Google Scholar Nie J, Lin B, Zhou M, Wu L, Zheng T. Role of ferroptosis in hepatocellular carcinoma. J Cancer Res...
Identification the ferroptosis-related gene signature in patients with esophageal adenocarcinoma. Cancer Cell Int. 2021;21(1):124. 50. Lu T, Xu R, Li Q, Zhao J-Y, Peng B, Zhang H, Guo J-d, Zhang S-Q, Li H-W, Wang J, et al. Systematic profiling of ferroptosis gene signatures...
Clear cell renal cell carcinoma (ccRCC) is still highly aggressive and lethal even with various therapeutic approaches. As the kidney is an iron metabolism-related organ, exploring and assessing the clinical value of ferroptosis, an iron-dependent regula
Further, current research speculated that TGF-β2 affected the expression of GPX4, nuclear factor E2-related factor 2 (NRF2), HO-1, NOX4, and ACSL4 to promote ferroptosis [196,197,198,199,200,201]. Thus, the combination of TGF-β and ferroptosis could have a prospective therapeutic ...