Taken together, this study established a novel ferroptosis-related gene signature and discovered a crucial gene, GCLC, that might be a new prognostic biomarker of LUAD patients, as well as provide a potential therapeutic target for LUAD patients.Luo, Lianxiang...
detailed GSVA function and parameter settings as follow: gsva(as.matrix(Normalized gene expression matrix), gene signature, method = “ssgsea”, verbose = FALSE, kcdf = “Gaussian”). Gene signatures used in this
ESTIMATE analysis is a computational method that measures the level of immune infiltration in tumor samples using gene expression data that indicates the presence of stromal and immune cell gene signatures. The ESTIMATE package for R [38] was used to estimate variations in immune scores between cont...
the choices in the diagnosis and treatment of melanoma and the prognostic judgment, we used data from databases including TCGA, GTEx, GEO and previous studies to analyze iron death-related genes in melanoma and construct a ferroptosis-related gene model that can be employed for prognosis prediction...
Additionally, a gene set enrichment analysis (GSEA) was performed to investigate the functions of the key target genes, and the mRNA-miRNA and TF-mRNA regulatory networks were developed to explore the potential regulation of these key genes. Furthermore, the intermolecular interactions between key ...
The ferroptosis-related gene SLC1A5 was upregulated in STAD (P<0.001) and was associated with better prognosis (P=0.049). The CIBERSORT database and Spearman correlation analysis indicated that SLC1A5 was correlated with eight types of tumor-infiltrating immune cells and immune checkpoints, ...
The gene expression profile of abdominal aortic aneurysm (AAA) neck is not fully understood. The etiology of AAA is considered to be related to atherosclerosis and the inflammatory response, involving congenital, genetic, metabolic, and other factors. Th
We conducted Gene Ontology (GO) enrichment analyses of the FRGs by using packages such as “ggplot2” and “cluster profile”. The three criteria for the enriched GO terms included: biological process (BP), cellular component (CC), and molecular function (MF). Kyoto Encyclopedia of Gene and...
Integrated bioinformatics analysis identifies a Ferroptosis-related gene signature as prognosis model and potential therapeutic target of bladder cancer Background Bladder cancer (BLCA) is one of the most prevalent cancers worldwide. Ferroptosis is a newly discovered form of non-apoptotic cell death that...
Objective Cardiovascular diseases (CVDs) are major public health problems that threaten the lives and health of individuals. The article has reviewed recent progresses about ferroptosis and ferroptosis-related intervention approaches for the treatment of CVDs and provided more references and strategies for ...