The human Hrs and STAM proteins comprise the ESCRT-0 complex, which has a pivotal role in directing ubiquitinated cell surface receptors to the lysosomal degradation pathway. Here we report a structural model for the complete ESCRT-0 complex based on the high resolution structure of the Hrs-STAM...
病毒进入细胞后,通过Escape complex复合物作用于ESCRT复合物,使其形成过度聚集的状态,从而形成病毒内泡并被释放出细胞质膜。当然,不同的病毒还有各自特有的机制。 4.ESCRT在细胞质质膜修复中的作用分类 最近的研究表明ESCRT还能参与细胞内直接修复的过程。当细胞膜断裂时,ESCRT和皮酰酰转移酶可快速地协同作用于断裂位置...
Knockdown of HGS destabilized ESCRT-0 complex and inhibited core protein expression and HBV replication.ShuFan, ChouMingLin, TsaiJyunYuan, HuangYaShu, ChangChiaho, Shih
thereby generating multi- vesicular bodies that deliver the cargo to lysosomes.2,3 The initial recognition of ubiquitinated cargo and recruitment of ESCRT-I is conducted by the ESCRT-0 complex, which contains two subunits, hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) and signal...
The target of rapamycin complex 1 (TORC1), a nutrient-activated central regulator of cell growth, directly phosphorylates Vps27 to antagonize its function in microautophagy, but whether this also serves to restrain MVB sorting at endosomes is still an open question. Here, we show that TORC1 ...
Unexpectedly, a null mutant in Hrs, encoding one of the components of the ESCRT-0 complex, which acts upstream of ESCRT-I, -II, -III in MVE sorting is dispensable for tumor suppression. Here, we report that two Drosophila epithelia lacking activity of Stam, the other known components of ...
The endosomal sorting complex required for transport (ESCRT) protein complexes function at the endosome in the formation of intraluminal vesicles (ILVs) containing cargo proteins destined for the vacuolar/lysosomal lumen. The early ESCRTs (ESCRT-0 and -I) are likely involved in cargo sorting, wher...
Proteins of the ESCRT (endosomal sorting complex required for transport) complex function in membrane fission processes, such as multivesicular body (MVBs) formation, the terminal stages of cytokinesis, and separation of enveloped viruses from the plasma membrane. In mammalian cells, the machinery consi...
AMSH regulates CXCR4 stability and trafficking through association with the ESCRT-0 complexReversible ubiquitination is essential for the endocytic sorting and downregulation of G protein-coupled receptors, as illustrated by the CXC chemokine receptor 4 (CXCR4). T...
AMSH regulates CXCR4 stability and trafficking through association with the ESCRT-0 complex.Reversible ubiquitination is essential for the endocytic sorting and down-regulation of G protein-coupled receptors, as illustrated by the CXC chemokine receptor 4 (CXCR4). The deubiquitinating enzyme Associated ...