H. (2009) Hybrid structural model of the complete human ESCRT-0 complex. Structure 17, 406-416Ren X, Kloer DP, Kim YC, Ghirlando R, Saidi LF, Hummer G, Hurley JH. Hybrid structural model of the complete human ESCRT-0 complex. Structure 2009;17:406-416. [PubMed: 19278655]...
病毒进入细胞后,通过Escape complex复合物作用于ESCRT复合物,使其形成过度聚集的状态,从而形成病毒内泡并被释放出细胞质膜。当然,不同的病毒还有各自特有的机制。 4.ESCRT在细胞质质膜修复中的作用分类 最近的研究表明ESCRT还能参与细胞内直接修复的过程。当细胞膜断裂时,ESCRT和皮酰酰转移酶可快速地协同作用于断裂位置...
BMC Biology (2021) 19:153 https://doi.org/10.1186/s12915-021-01091-4 RESEARCH ARTICLE Open Access The ESCRT-0 subcomplex component Hrs/ Hgs is a master regulator of myogenesis via modulation of signaling and degradation pathways L. Coudert , A. Osseni , Y. G. Gangloff , L. Schaeffer ...
thereby generating multi- vesicular bodies that deliver the cargo to lysosomes.2,3 The initial recognition of ubiquitinated cargo and recruitment of ESCRT-I is conducted by the ESCRT-0 complex, which contains two subunits, hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) and signal...
To elucidate this binding specificity, we determined the complex structure of the HD-PTP Bro1 domain bound to the STAM2 core region. STAM2 binds to the hydrophobic concave pocket of the HD-PTP Bro1 domain, as CHMP4B does to the pocket of Alix, Brox, or HD-PTP but in the opposite ...
Knockdown of HGS destabilized ESCRT-0 complex and inhibited core protein expression and HBV replication.ShuFan, ChouMingLin, TsaiJyunYuan, HuangYaShu, ChangChiaho, Shih
Unexpectedly, a null mutant in Hrs, encoding one of the components of the ESCRT-0 complex, which acts upstream of ESCRT-I, -II, -III in MVE sorting is dispensable for tumor suppression. Here, we report that two Drosophila epithelia lacking activity of Stam, the other known components of ...
As a further validation of complex formation with ESCRT proteins, co-immunoprecipitation was performed on transiently expressed myc-Endofin. Indeed, Endofin showed to form a complex with HD-PTP, ESCRT-0 (Hrs and STAM2) and ESCRT-I (Tsg101 and UBAP1) (Figure 1B), where STAM2, Tsg101...
Hybrid structural model of the complete human ESCRT-0 complex. Structure. 2009; 17 :406–416.Ren X, Kloer DP, Kim YC, Ghirlando R, Saidi LF, Hummer G, Hurley JH. Structure. 2009; 17 :406–416.Ren X, Kloer DP, Kim YC, Ghirlando R, Saidi LF, et al. Hybrid structural model ...
The endosomal sorting complex required for transport (ESCRT) protein complexes function at the endosome in the formation of intraluminal vesicles (ILVs) containing cargo proteins destined for the vacuolar/lysosomal lumen. The early ESCRTs (ESCRT-0 and -I) are likely involved in cargo sorting, wher...