Interestingly, ESCRT-II simultaneously bound directly to RNA and membranes and was sufficient to tether RNA to specific phospholipids. Furthermore, immunodepletion of ESCRT-II from egg extract abolished mRNA localization to endosomes. Additionally, we show some evidence to suggest that ESCRT-II is ...
J. (2012). ESCRT-II's involvement in HIV-1 genomic RNA trafficking and assembly. Biol Cell 104, 706-721.Ghoujal B, Milev MP, Ajamian L, Abel K, Mouland AJ. ESCRT-II's involvement in HIV-1 genomic RNA trafficking and assembly. Biol Cell. 2012;104:706-21....
ESCRT-II forms a stable, soluble complex of defined stoichiometry. In contrast, the ESCRT-III subunits are cytosolic and monomeric until they are recruited to membranes, a process that is dependent on ESCRT-II (Babst et al., 2002a). Interactions within the ESCRT complexes have been extensively...
The 3.6 structure of the yeast ESCRT-II core presented here reveals a trilobal complex containing two copies of Vps25, one copy of Vps22, and the C-terminal region of Vps36. Unexpectedly, the entire ESCRT-II core consists of eight repeats of a common building block, a "winged helix" ...
We identify a constitutively active mutant of ESCRT-II that partially suppresses the phenotype of an ESCRT-I or ESCRT-0 deletion strain, suggesting that these early ESCRTs are not essential and have redundant functions. However, the ESCRT-III/Vps4 system alone is not sufficient for ILV ...
ESCRTs-0, -I, and -II are soluble hetero-oligomers that are recruited to cargo-laden endosomes by binding both the compartment-specific lipid phosphatidylinositol-3-phosphate (PtdIns(3)P) and ubiquitin-modified cargo. In addition, the ESCRT-II complex also initiates the assembly of ESCRT-III....
E.; (2006). Genetic structure and evolution of the Vps25 family, a yeast ESCRT-II component. BMC Evol Biol, 6, (Aug, 2006), 59.Slater R, Bishop NE . ( 2006 ). Genetic structure and evolution of the Vps25 family, a yeast ESCRT-II component . BMC Evol Biol 6 , 59...
英文名称:SNF8, NT (SNF8, EAP30, Vacuolar-sorting protein SNF8, ELL-associated protein of 30kD, ESCRT-II complex subunit VPS22) 英文同义词:SNF8, NT (SNF8, EAP30, Vacuolar-sorting protein SNF8, ELL-associated protein of 30kD, ESCRT-II complex subunit VPS22) ...
Alternative cellular factors that are known to be capable of regulating ESCRT-III function include the ESCRT-II complex and other members of the Bro1 family. We therefore used small interfering RNA (siRNA) to knock down the essential ESCRT-II subunit EAP20/VPS25 (ELL-associated protein 20/...
英文别名: SNF8, NT (SNF8, EAP30, Vacuolar-sorting protein SNF8, ELL-associated protein of 30kD, ESCRT-II complex subunit VPS22)中文名: 中文别名: CBNumber: CB04976185 分子式: 分子量: 0 MOL File: Mol file 化学性质 安全信息 用途 供应商 1 SNF8, NT (SNF8, EAP30, Vacuolar-sorting ...