In this study, we show that the endosomal sorting complex required for transport III (ESCRT-III) in budding yeast regulates macromitophagy induced by nitrogen starvation, but not by the post-logarithmic phase growth in lactate medium by monitoring a mitochondrial marker, Om45. Firstly, loss of ...
Using budding yeast gametogenesis as a model, we show here that the endosomal sorting complex required for transport (ESCRT) III regulates nuclear envelope organization. During gametogenesis, the nuclear pore complex (NPC) and other senescence factors are sequestered away from the prospore nuclei. We...
ESCRT-III complex is activated during ferroptosis and antagonizes cell death It has been previously reported that during necroptosis and pyroptosis, membrane repair dependent on the action of the ESCRT-III complex delays cell death [17, 22, 23]. To investigate the role of ESCRT-III complex in...
(ESCRT)-III complex is the major membrane remodelling complex that drives intra-lumenal-vesicle (ILV) formation on endosomal membranes. Here we used a fluorescent membrane-tension probe to show that ESCRT-III subunits are recruited onto endosomal membranes when the membrane tension is reduced. We ...
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The soluble coiled-coil-containing proteins Vps2, Vps20, Vps24, and Snf7 are recruited from the cytoplasm to endosomal membranes where they oligomerize into a protein complex, ESCRT-III. ESCRT-III contains two functionally distinct subcomplexes. The Vps20-Snf7 subcomplex binds to the endosomal ...
through classical assembly of the ESCRT-III complex. The p97 AAA-ATPase controls both phases of NE reformation; together with its adaptor protein p47, it regulates membrane delivery and NEexpansion, whereas through its adaptors nuclear protein local- ...
Negative membrane curvature catalyzes nucleation of endosomal sorting complex required for transport (ESCRT)-III assembly 来自 Semantic Scholar 喜欢 0 阅读量: 98 作者:IH Lee,H Kai,LA Carlson,JT Groves,JH Hurley 摘要: The endosomal sorting complexes required for transport (ESCRT) machinery functions ...
In this system, a macromolecular complex in the nucleus buds through the INM to form a vesicle in the perinuclear space that then fuses with the outer nuclear membrane (ONM) to release the complex into the cytoplasm28. We also reported that ESCRT-III is required for the proper integrity of...
In contrast, the endosomal sorting complex required for transport-III (ESCRT-III), an evolutionarily conserved protein complex with membrane fission machinery, plays a key role in the repair of damaged plasma membranes in various types of regulated cell death, such as necroptosis, pyroptosis, and ...