Adell MA, Teis D (2011) Assembly and disassembly of the ESCRT-III membrane scission complex. FEBS Lett 585: 3191 - 3196Adell, M. A., and Teis, D. (2011) Assembly and disassembly of the ESCRT- III membrane scission complex. FEBS Lett. 585, 3191-3196...
Revolving around constriction by ESCRT-III The endosomal sorting complex required for transport (ESCRT)-III is critical for membrane abscission; however, the mechanism underlying ESCRT-III-mediated membrane constriction remains elusive. A study of the dynamic assembly and disassembly of the ESCRT-III ...
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Also, we demonstrate that ESCRT-III assembly drives membrane deformation. Furthermore, using an in vitro disassembly assay, we directly demonstrate that Vps24 and Vps2 function as adaptors in the ATP-dependent membrane disassembly of the ESCRT-III complex by recruiting the AAA ATPase Vps4....
The Snf7 oligomer is “capped” by Vps24 and Vps2, which are recruited after Snf7 oligomerization and function to: (1) halt Snf7 filament progression, and (2) recruit Vps4-Vta1 for ESCRT-III complex disassembly. Snf7 oligomerization can also be manipulated by modulating the expression of...
et al. Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing. Nature 522, 231–23 (2015). Article ADS CAS PubMed Google Scholar Webster, B. M., Colombi, P., Jager, J. & Lusk, P. Surveillance of Nuclear Pore Complex Assembly by ESCRT-III/Vps4. ...
[PDF] Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing 热度: Handbook of Nuclear Engineering (5 Volume set)-Volume 4 Reactors of Generations III and IV_部分1 热度: Handbook of Nuclear Engineering (5 Volume set)-Volume 4 Reactors of Generations III and IV...
(or 'inverse')-topology membrane scission is carried out by the endosomal sorting complex required for transport (ESCRT) proteins, which form filaments, flat spirals, tubes and conical funnels that are thought to direct membrane remodelling and scission. Their assembly, and their disassembly by the...
by Vps4, which interacts with the ESCRT-III proteins Vps2, Did2, Vps20, Vps24 and Snf7. The authors expressed Vps4-interaction-deficient ESCRT mutants in yeast, and found that mutations in Vps2 and Snf7 reduced Vps4 association with the ESCRT-III complex and blocked complex disassembly...
In this system, a macromolecular complex in the nucleus buds through the INM to form a vesicle in the perinuclear space that then fuses with the outer nuclear membrane (ONM) to release the complex into the cytoplasm28. We also reported that ESCRT-III is required for the proper integrity of...