内吞体运输必需分选复合物(endosomal sorting complex required for transport,ESCRT)是一种保守的膜重塑复合物,在许多涉及膜重塑事件的过程中可以进行膜切割。ESCRT包括4种主要核心复合物(ESCRT-0、ESCRT-Ⅰ、ESCRT-Ⅱ、ESCRT-Ⅲ)及辅助蛋白ALIX、AAA ATPase...
(2009). Hybrid structural model of the complete human ESCRT- 0 complex. Structure 17, 406-416.Ren X, Kloer DP, Kim YC, Ghirlando R, Saidi LF, et al. Hybrid structural model of the complete human ESCRT-0 complex. Structure. 2009; 17 :406–16....
ESCRT-0 In metazoa and fungi, MVB-mediated sorting of ubiquitinated membrane proteins (or cargoes) starts with cargo capture by ESCRT-0, which is a heteromeric multivalent ubiquitin-binding protein complex consisting of two subunits, VPS27/hepatocyte growth factor-regulated tyrosine kinase substrate (...
病毒进入细胞后,通过Escape complex复合物作用于ESCRT复合物,使其形成过度聚集的状态,从而形成病毒内泡并被释放出细胞质膜。当然,不同的病毒还有各自特有的机制。 4.ESCRT在细胞质质膜修复中的作用分类 最近的研究表明ESCRT还能参与细胞内直接修复的过程。当细胞膜断裂时,ESCRT和皮酰酰转移酶可快速地协同作用于断裂位置...
(ESCRT-I, -II, -III, and the VPS4/SKD1 complex) and several ESCRT accessory proteins, but lacks of the ESCRT-0. Every ESCRT complex contains several subunit proteins. Recent researches have demonstrated that the ESCRT machinery plays an essential role in the vacuolar sorting of ubiquitinated...
New component of ESCRT-I regulates endosomal sorting complex assembly Source: Rockefeller University Press A PPxY motif within the VP40 protein of Ebola virus interacts physically and functionally with a ubiquitin ligase: implications for filovirus budding. ...
BMC Biology (2021) 19:153 https://doi.org/10.1186/s12915-021-01091-4 RESEARCH ARTICLE Open Access The ESCRT-0 subcomplex component Hrs/ Hgs is a master regulator of myogenesis via modulation of signaling and degradation pathways L. Coudert , A. Osseni , Y. G. Gangloff , L. Schaeffer ...
摘 要: 内吞体分选转运复合体 (Endosomal sorting complex required for transport ,ESCRT) 主要识别泛素化 修饰的膜蛋白,介导内吞小泡出芽和多泡体 (Multivesicular bodies ,MVBs) 的形成。此外,以类似的拓扑方 式,ESCRT 也参与胞质分裂、自体吞噬、以及包膜病毒的出芽等过程。已有的研究表明,大量的反转录病毒 和...
These five protein complexes (ESCRT-0, -I, -II, -III, and the Vps4 complex) sort and package these internalized surface proteins into IntraLumenal Vesicles (ILVs)3. After many rounds, ILVs accumulate creating a mature multivesicular body (MVB)21,22. The MVB then fuses with lysosomes to...