Multivesicular endosome (MVE) sorting depends on proteins of the Endosomal Sorting Complex Required for Transport (ESCRT) family. These are organized in four complexes (ESCRT-0, -I, -II, -III) that act in a sequential fashion to deliver ubiquitylated cargoes into the internal luminal vesicles (...
BMC Biology (2021) 19:153 https://doi.org/10.1186/s12915-021-01091-4 RESEARCH ARTICLE Open Access The ESCRT-0 subcomplex component Hrs/ Hgs is a master regulator of myogenesis via modulation of signaling and degradation pathways L. Coudert , A. Osseni , Y. G. Gangloff , L. Schaeffer ...
Flotillin-1 depletion impairs cargo delivery from ESCRT-0 During sorting, the cargo delivery from ESCRT-0 to ESCRT-I is mediated by the interaction of Hrs and Tsg101.12 Our data show that flotillin-1 interacts with both Hrs and Tsg101, which might implicate a role in cargo transfer between ...
Cells expressing a catalytically inactive mutant of AMSH show basal hyperubiquitination, but not increased degradation, of the ESCRT-0 components STAM1 and Hrs. This is dependent on the RXXK motif of AMSH. Ubiquitination of endocytic machinery modulates their activity, suggesting that AMSH may ...
Internalized and ubiquitinated signaling receptors are silenced by their intraluminal budding into multivesicular bodies aided by the endosomal sorting complexes required for transport (ESCRT) machinery. HD-PTP, an ESCRT protein, forms complexes with ESCRT-0, -I and -III proteins, and binds to Endof...
HD-PTP is a cytosolic protein tyrosine phosphatase, and is associated with EGFR trafficking by interacting with the ESCRT-0 protein STAM2 and the ESCRT-III protein CHMP4B via its N-terminal Bro1 domain. Intriguingly, the homologous domain of two other human Bro1 domain-containing proteins, ...
1.ESCRT在细胞内膜再循环中的作用分类 ESCRT可将不需要的膜蛋白质转移至泡膜,并将泡膜剥离至细胞外,实现内膜蛋白质的再利用。ESCRT-I和ESCRT-II复合物可结合膜蛋白质,因而能够捆绑膜泡以形成内肿,并将内泡表示到内质网上的细胞膜。随后,ESCRT-III和Vps4复合物作用于膜泡脖颈,随着膜泡被切断并与细胞质膜分离。
在坏死和焦亡过程中,依赖于ESCRT-III复合物作用的膜修复可以延缓细胞死亡。作者使用CHMP4B斑点形成作为代替ESCRT-III激活。最初,CHMP4B主要表现为均匀的胞质分布,然而,在RSL3处理后,该蛋白定位于不同的点状结构,随着时间的推移,其数量和荧光强度都...
研究人员发现果蝇中去泛素酶USP8的缺失可以将生殖细胞的不完全分裂转化为完全分裂;相反,在生殖系干细胞(GSCs)中过表达USP8足以实现从完全分裂到不完全分裂的反向转化。USP8通过对ESCRT-III蛋白CHMP2B和Shrub/CHMP4的去泛素化实现对两种细胞...
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