Two papers published in a recent issue of Cell provide insights into the structural organization and functional interactions of the ESCRT-I complex and ESCRT-II GLUE domain.doi:10.1016/j.str.2006.03.005Sudharshan EathirajDavid G. Lambright
The ESCRT-III complex is shown to counteract the loss of plasma membrane integrity in cells undergoing necroptosis, thereby preventing or delaying cell death. Paulina Strzyz Research Highlights21 Apr 2017 Nature Reviews Molecular Cell Biology Volume: 18, P: 343 Archaeal virus escapology Visualizat...
ESCRT复合物是Endosomal Sorting Complex Required for Transport的缩写,由多个亚基组成,包括ESCRT-I、ESCRT-II、ESCRT-III和Vps4等。在细胞膜动态变化中,ESCRT复合物居于关键的地位。研究表明,ESCRT复合物通过对内部囊泡和膜蛋白的选择和作用,能够有效的调节细胞膜形态的变化以适应不同的细胞生理需求。ESCRT复合体的结构...
review, we firstly introduce the subunits and biological functions of the ESCRT machinery in plants, and then summarize the latest research advances on the plant-specific ESCRT complex components. Finally, we discuss future study on the unsolved scientific problems of the ESCRT complex in plants....
Multivesicular bodies (MVBs) are crucial intermediates in the trafficking of ubiquitinated receptors and other cargo destined for lysosomes. The formation of MVBs by invagination of the endosomal limiting membrane is catalyzed by the endosomal sorting complex required for transport (ESCRT) complexes, a ...
内吞体运输必需分选复合物(endosomal sorting complex required for transport,ESCRT)是与膜重塑密切相关的复合物,在许多涉及膜重塑事件中起重要作用,包括病毒出芽、细胞分裂、神经元修剪、多泡体形成等。ESCRT含多种亚基,不同亚基相互配合协同完成复合物的生物...
内体分拣转运复合物系统（endosomal sorting complex required for transport, ESCRT）是一个多功能的蛋白转运及膜剪切机器，参与调控膜蛋白和脂质的循环及降解过程。泛素相关蛋白1（UBAP1）是ESCRT的成员之一，其截短突变会导致一种以皮质脊髓束异常为主要特征的神经退行性疾病-遗传性痉挛性截瘫（hereditary spastic ...
内体分拣转运复合物系统(endosomal sorting complex required for transport, ESCRT)是一个多功能的蛋白转运及膜剪切机器,参与调控膜蛋白和脂质的循环及降解过程。泛素相关蛋白1(UBAP1)是ESCRT的成员之一,其截短突变会导致一种以皮质脊髓束异常为主要特征的神经退行性疾病-遗传性痉挛性截瘫(hereditary spastic paraplegia...
Figure 1The endosomal sorting complex required for transport (ESCRT) mechanism and the endocytosis of ubiquitinated membrane proteins in Arabidopsis Extracellular proteins, materials and newly synthesized proteins are transported to trans Golgi network (TGN) via the endocytic or the secretory pathway, respe...
Cell division and the ESCRT complex: a surprise from the archaea. Commun. Integr. Biol. 2009; 2:86-88. [PubMed: 19704896]Ettema, T.J. and R. Bernander, Cell division and the ESCRT complex: A surprise from the archaea. Commun Integr Biol, 2009. 2(2): p. 86-8....