Xiao-Wei Qin1,2,Yi-Fan Lin3, Jian He2, Nan-Nan Chen1, Chang Liu1, Shao-Ping Weng2, Jian-Guo He1,3 & Chang-Jun Guo1,2,3 The cellular endosomal sorting complex required for transport (ESCRT) pathway is a multifunctional pathway involved in cell physiological activit...
Current models hold that ubiquitin-binding ESCRT factors act early in the pathway to regulate factor recruitment and assembly, whereas the late acting ESCRT-III proteins form filaments that draw the membranes together and mediate fission, possibly, in collaboration with VPS4-ATPases. I will ...
4. Vietri M, Radulovic M, Stenmark H. The many functions of ESCRTs. Nat Rev Mol Cell Biol, 2020, 21(1): 25-42 5. Henne W M, Buchkovich N J, Emr S D. The ESCRT pathway. Dev Cell, 2011, 21(1): 77-91 6. Trajkovic K, Hsu C, Chiantia S, et al. Ceramide triggers buddi...
2023年12月19日,山东大学高成江及刘冰玉共同通讯在PNAS上在线发表题为“Listerin promotes cGAS protein degradation through the ESCRT pathway to negatively regulate cGAS-mediated immune response”的研究论文,该研究发现Listerin是cGAS介导的天然免疫反应的负调控因子,能促进cGAS的蛋白降解。 研究结果表明,内体分选复合...
These results reveal a critical role for an ESCRT pathway-dependent LE/LY trafficking step in Src function by promoting localization of active Src to FAs. 展开 关键词: cell migration, endosomal sorting complexes required for transport, focal adhesion, late endosomal trafficking DOI: 10.1073/pnas...
In mammals, two early acting proteins of the ESCRT pathway, ALIX and TSG101, are recruited to the midbody through direct interactions with the phosphoprotein CEP55. CEP55 resides at the centrosome through most of the cell cycle but then migrates to the midbody at the start of cytokinesis. ...
While the majority of RNA viruses bearing L-domains are known to hijack the ESCRT pathway to complete the budding process, the budding of large and complex enveloped DNA viruses, especially iridoviruses, has been rarely investigated. In the present study, we use the tiger frog virus (TFV) ...
Molecular mechanisms of the membrane sculpting ESCRT pathway. Cold Spring Harbor Perspect Biol 2013; 5: a016766. 3 Katzmann DJ, Babst M, Emr SD. Ubiquitin-dependent sorting into the multi- vesicular body pathway requires the function of a conserved endosomal protein sorting complex ESCRT-I. Cell...
Surprisingly, we established that GFP-YUC1, a soluble protein, was sorted to vacuoles through the ESCRT pathway, which has long been recognized for sorting and targeting integral membrane proteins. We further show that GFP-YUC1 was ubiquitinated and in this form GFP-YUC1 was targeted for ...
Extracellular proteins, materials and newly synthesized proteins are transported to trans Golgi network (TGN) via the endocytic or the secretory pathway, respectively. The ubiquitinated membrane proteins are then recognized by ESCRT machinery and be transported into the lumen of MVB/PVC via intraluminal...