4. Vietri M, Radulovic M, Stenmark H. The many functions of ESCRTs. Nat Rev Mol Cell Biol, 2020, 21(1): 25-42 5. Henne W M, Buchkovich N J, Emr S D. The ESCRT pathway. Dev Cell, 2011, 21(1): 77-91 6. Trajkovic K, Hsu C, Chiantia S, et al. Ceramide triggers buddi...
The ESCRT (endosomal sorting complex required for transport) pathway is a key mediator of MVB biogenesis, but it also plays critical roles in retroviral budding and cytokinetic abscission. Despite these diverse roles, the ESCRT pathway can be simply seen as a cargo-recognition and membrane-...
2023年12月19日,山东大学高成江及刘冰玉共同通讯在PNAS上在线发表题为“Listerin promotes cGAS protein degradation through the ESCRT pathway to negatively regulate cGAS-mediated immune response”的研究论文,该研究发现Listerin是cGAS介导的天然免疫反应的负调控因子,能促进cGAS的蛋白降解。 研究结果表明,内体分选复合...
Xiao-Wei Qin1,2,Yi-Fan Lin3, Jian He2, Nan-Nan Chen1, Chang Liu1, Shao-Ping Weng2, Jian-Guo He1,3 & Chang-Jun Guo1,2,3 The cellular endosomal sorting complex required for transport (ESCRT) pathway is a multifunctional pathway involved in cell physiological activit...
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ESCRT pathway proteins play a key role in sorting ubiquitinated membrane receptors towards lysosomes providing an important mechanism for attenuating cell surface receptor signaling. However, recent studies point to a positive role of ESCRT proteins in signal transduction in multiple species studied under ...
While the majority of RNA viruses bearing L-domains are known to hijack the ESCRT pathway to complete the budding process, the budding of large and complex enveloped DNA viruses, especially iridoviruses, has been rarely investigated. In the present study, we use the tiger frog virus (TFV) ...
exosome biogenesis pathway mainly contains three key steps accompanied by endosomal vesicular transport: ILV formation, prevention of MVEs degradation and the fusion of MVEs with the cell surface.1The regulatory mechanism of the balance between degradative and secretory capacity of MVEs remains largely...
pathway. Dev Cell, 2011, 21(1): 77−91. [15] Morita E, Sundquist WI. Retrovirus budding. Annu [3] Hurley JH, Hanson PI. Membrane budding and Rev Cell Dev Biol, 2004, 20: 395−425. scission by the ESCRT machinery: its all in the [16] Calistri A, Salata C, Parolin C, ...
11. Marina Vietri, et al. The many functions of ESCRTs. Nat Rev Mol Cell Biol. 2020 Jan;21(1):25-42. 12.Matias Ostrowski, et al. Rab27a and Rab27b control different steps of the exosome secretion pathway. Nat Cell Biol. 2010 Jan;12(1):19-30; sup pp 1-13....