A conserved ubiquitin- and ESCRT-dependent pathway to regulate human lysosomal membrane proteinsdoi:10.1101/2020.11.18.389296Weichao ZhangXi YangLiang ChenYun-Yu LiuVarsha VenkataranganLucas ReistPhyllis HansonHaoxing XuYanzhuang WangMing LiCold Spring Harbor Laboratory...
Ubiquitin-dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex, ESCRT-I. CELL 106, 145 (2001). 39. MC, J. & JL, S. The C-Terminal Half of TSG101 Blocks Rous Sarcoma Virus Budding and Sequesters Gag into Unique Non...
These results reveal a critical role for an ESCRT pathway-dependent LE/LY trafficking step in Src function by promoting localization of active Src to FAs. 展开 关键词: cell migration, endosomal sorting complexes required for transport, focal adhesion, late endosomal trafficking DOI: 10.1073/pnas...
6c). Together, these results suggest that the RAB31-FLOTs machinery marks a lipid raft microdomains-dependent exosome pathway that controls RTKs sorting into exosomes. In addition, CD9, CD81, CD63, Syntenin-1 and Alix in the concentrated conditional media from FLOTs-depleted NCI-H1975 or HeLa...
Our data indicate that this ALIX- and ESCRT-III–dependent pathway promotes the sorting and delivery of tetraspanins to exosomes. We conclude that ALIX provides an additional pathway of ILV formation, secondary to the canonical pathway, and that this pathway controls the targeting of exosomal ...
Show abstract A conserved ubiquitin- And ESCRT-dependent pathway internalizes human lysosomal membrane proteins for degradation 2021, PLoS Biology Show abstract1 Present address. Laboratory of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Nishi-ku, Kumamoto, 860...
Endosomal-sortingcomplexesrequiredfortransport (ESCRT)pathway-dependentendosomaltraffic regulatesthelocalizationofactiveSrcatfocaladhesions ChunTu a,b ,CesarF.Ortega-Cava a,b ,PaulWinograd c ,MarissaJoStanton a,b ,AlagarsamyLakkuReddi d ,IngridDodge e , RanjanaArya f ,ManjariDimri g ,RobertJ....
摘 要: 内吞体分选转运复合体 (Endosomal sorting complex required for transport ,ESCRT) 主要识别泛素化 修饰的膜蛋白,介导内吞小泡出芽和多泡体 (Multivesicular bodies ,MVBs) 的形成。此外,以类似的拓扑方 式,ESCRT 也参与胞质分裂、自体吞噬、以及包膜病毒的出芽等过程。已有的研究表明,大量的反转录病毒 和...
In insulin target tissues, GLUT4 is known to traffic through multiple compartments that may involve ubiquitin- and/or SUMO-dependent targeting. During these trafficking steps, GLUT4 is sorted into a storage reservoir compartment that is acutely released by insulin signalling processes that are downstre...
(OMM) in an OA-dependent manner (Fig.3c), whereas the other region from residues 613-913 failed to localize to the OMM (Supplementary Fig.2d, e). This region of VPS13D (residues 404–612) is referred to as VPS13D_N hereafter. Cell fractionation experiments confirmed the enrichment of ...