a key checkpoint must suppress ILVs degradation by preventing the fusion of MVEs with lysosomes.1The accumulated nondegradable MVEs use the common secretory machineries for exosome secretion, which is mainly regulated by RAB27.1,15Therefore, exosome biogenesis pathway mainly contains three key steps a...
This K63-linked polyubiquitination facilitates the sorting and degradation of RIGI and IFIH1 proteins through the ESCRT-dependent pathway. Concordantly, LTN1 deficiency enhances the innate antiviral response to infection with RNA viruses. Thus, our work uncovers a new mechanism for RIGI and IFIH1 ...
(2010). Endosomal-sorting complexes required for transport (ESCRT) pathway-dependent endosomal traffic regulates the localization of active Src at focal ... A Tiwari,JJ Jung,SM Inamdar,... - 《Journal of Biological Chemistry》 被引量: 0发表: 2011年 The Human Endosomal Sorting Complex Required ...
ESCRTs were first defined as a ubiquitin-dependent protein-sorting pathway in yeast. Earlier studies in the 1980s and 1990s in the Emr and Stevens laboratories had identified numerous genes in Saccharomyces cerevisiae yeast that, when lost, displayed vps defects (Banta et al., 1988, Robinson et...
Ubiquitin-dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex, ESCRT-I. CELL 106, 145 (2001). 39. MC, J. & JL, S. The C-Terminal Half of TSG101 Blocks Rous Sarcoma Virus Budding and Sequesters Gag into Unique Non...
Ubiquitin-dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex, ESCRT-I. CELL 106, 145 (2001). 39. MC, J. & JL, S. The C-Terminal Half of TSG101 Blocks Rous Sarcoma Virus Budding and Sequesters Gag into Unique Non...
In general, mammalian MVEs tend to accumulate near the center of cells at steady state [26], in a manner dependent on dynein-mediated transport [27], which positions them well to receive biosynthetic cargoes from the perinuclear trans-Golgi network. However, a large number of cargoes also ...
摘 要: 内吞体分选转运复合体 (Endosomal sorting complex required for transport ,ESCRT) 主要识别泛素化 修饰的膜蛋白,介导内吞小泡出芽和多泡体 (Multivesicular bodies ,MVBs) 的形成。此外,以类似的拓扑方 式,ESCRT 也参与胞质分裂、自体吞噬、以及包膜病毒的出芽等过程。已有的研究表明,大量的反转录病毒 和...
A Conserved Ubiquitin- and ESCRT-Dependent Pathway Internalizes Human Lysosomal Membrane Proteins for Degradation. PLoS Biol. 2021, 19, e3001361. [Google Scholar] [CrossRef] [PubMed] Wróbel, M.; Cendrowski, J.; Szymańska, E.; Grębowicz-Maciukiewicz, M.; Budick-Harmelin, N.; ...
1. ESCRT-Dependent Budding Budding is an integral part of virus infection where the objective is exit of a protected viral genome from the infected cells. By necessity, enveloped viruses use host-derived membrane to form the encapsidating membrane for this purpose. Since nucleic acid and lipid...