T cellsTヽell exhaustion is one of the hallmarks in cancer, but the mechanisms underlying Tヽell dysregulation remains unclear. Here, we reported that down‐regulation of transcription factor EOMES contributed to increased levels of inhibitory receptors in T cell among the tumour tissues and ...
4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors. Nat Med. 2015;21(6):581–90. https://doi.org/10.1038/nm.3838. Article CAS PubMed PubMed Central Google Scholar Lupar E, Brack M, Garnier L, Laffont S, Rauch KS, Schachtrup K,...
T cell exhaustionimmunotherapyimmune checkpoint blockadeAlthough anti-PD-1 and anti-CTLA-4 based immune checkpoint blockade (ICB) has represented a turning point in cancer care, clinical responses are observed only idoi:10.2139/ssrn.3464650Weulersse, Marianne...
These findings indicated that Eomes might be promising early warming targets of miscarriage. In addition, this study suggested that the reproductive safety must be a criterion considered in modulating the dose and function of Eomes in CD8+T cells to reverse T cell exhaustion. 展开 ...
In the periphery, memory CD8+T cell subpopulations can be identified and classified by the expression of surface markers, such as CD44, CD62L, Ly6C, CD103, CD122 (IL-2Rβ chain), or CXCR3. These adhesion molecules, cytokine or chemokine receptors define their functional properties and traff...
Overcoming T cell exhaustion in infection and cancer. Trends Immunol. 36, 265–276 (2015). 47. Kim, N. et al. MicroRNA-150 regulates the cytotoxicity of natural killers by targeting perforin-1. J. Allergy Clin. Immunol. 134, 195–203 (2014). 48. Shacklett, B.L., Critchfield, J.W...
19,20,21 Altogether, two main states of CD8 T cell exhaustion have been observed: a precursor subset (TOX+PD-1intTCF1+TIM3−T-bethiEOMESint) most abundantly found in secondary lymphoid tissues and able to differentiate in response to anti-PD-1 treatment and a terminally differentiated ...
T cell exhaustionimmunotherapyimmune checkpoint blockadeCD8 T cells within the tumor microenvironment (TME) are exposed to various signals that ultimately determine functional outcomes. Here, we examined the role of the co-activating receptor CD226 (DNAM-1) in CD8 T cell function. The absence of ...
Longitudinal characterization of CD8+ T cell exhaustion and T-bet/Eomes expression following ART initiation.Marcus BuggertJohanna TauriainenTakuya YamamotoJuliet FrederiksenMartin A. IvarssonJakob MichaëlssonOle LundBo HejdemanMarianne JanssonAnders Sönnerborg...