Drug-like Properties豆瓣评分:0.0 简介:Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become
如今有一种新型的筛选方式为SPR(structure-property relationships),算作对SAR的补充:一方面利用SAR(一种structure-based design)设计出高亲和力的化合物,再利用SRP(一种property-based design)的方式得到能顺利通过各种屏障、达到靶点的化合物。 Pharmaceuticals balance activit...
Drug-Like Properties: Concepts, Structure Design and Methods类药性:概念、结构设计与方法 读后感1 第2章 药物性质评估及良好类药性的优势 2.2 候选药物性质优化的主要方面 基于药代和安全性的影响性,按照化合物的性质归纳如下 : 结构性质 -亲脂性(Lipophilicity) -拓扑极性表面积(Topological polar surface area, ...
Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization, Second Edition, provides scientists and students the background and tools to understand, discover, and develop optimal clinical candidates. This valuable resource explores physiochemical properties, including ...
Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become a drug product. Understanding ADME/Tox is critical for all drug researchers, owing to its i...
drug-like properties-concepts,structure design and methods 星级: 549 页 Structure – ADME relationship still a long way to go 星级: 12 页 From in silico target prediction to multi-target drug design Current databases, methods and applications 星级: 21 页 RNA methods From sequence to str...
Drug-like Properties: Concepts, Structure Design and MethodsKerns, E.H., et al., Chapter 2 - Advantages of Good Drug-like Properties. Academic Press: San Diego., 2008; 6.Kerns EH, Di L. Advantages of good drug-like properties. Drug-Like Properties, Concepts, Structure Des...
Drug-like Properties (I)Rogério dos Santos AlvesAlex Soares de Souza, et all
当当中国进口图书旗舰店在线销售正版《【预订】Drug-Like Properties: Concepts, Structure Design and Methods from Adme to Toxic...》。最新《【预订】Drug-Like Properties: Concepts, Structure Design and Methods from Adme to Toxic...》简介、书评、试读、价格、图