Drug-like Properties (II): Physicochemical Properties 从前只是大概知道药物需要有适当的亲水性和亲脂性,合成药物有化学部分,筛选药物通过ADMET标准化的方法就行,其实这和不知道没什么区别。想知道一些行业的规则、手段,不得不去研究一下细节。还是试着探探水深,扒开皮...
Drug-Like Properties: Concepts, Structure Design and Methods类药性:概念、结构设计与方法 读后感1 第2章 药物性质评估及良好类药性的优势 2.2 候选药物性质优化的主要方面 基于药代和安全性的影响性,按照化合物的性质归纳如下 : 结构性质 -亲脂性(Lipophilicity) -拓扑极性表面积(Topological polar surface area, ...
Drug-like Properties豆瓣评分:0.0 简介:Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become
作者: 确定了一类新型高效、口服生物利用的HBV/HDV进入抑制剂,具有良好的类药属性(drug-like properties)。所发现的抑制剂干扰preS1的结合和NTCP介导的胆汁酸摄取,支持分子靶点是NTCP。这一系列进入抑制剂的先导优化正在进行中,预计将在2023年提名一个候选药物开发。 Assembly...
The authors describe how properties affect in vivo pharmacological activity and impact in vitro assays. Individual drug-like properties are discussed from a practical point of view, such as solubility, permeability and metabolic stability, with regard to fundamental understanding, applications of propert...
Drug-like Properties: Concepts, Structure Design and Methods Preface; Introductory Concepts; Physicochemical Properties; Disposition, Metabolism and Safety; Methods; Specific Topics; Answers to Problems; Appendix I: ... DEK Li - ELSEVIER 被引量: 110发表: 2016年 An Improved Small-Molecule Inhibitor ...
Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization, Second Edition, provides scientists and students the background and tools to understand, discover, and develop optimal clinical candidates. This valuable resource explores physiochemical properties, including ...
There are currently about 10000 drug-like compounds. These are sparsely, rather than uniformly, distributed through chemistry space. True diversity does not exist in experimental combinatorial chemistry screening libraries. Absorption, distribution, meta
Optimizing the "Drug-Like" Properties of Leads in Drug Discovery 电子书 图书目录 facebooklinkedinmastodonmessengerpinterestreddittelegramtwittervibervkontaktewhatsapp复制链接 想要找书就要到本本书屋 onlinetoolsland.com 立刻按ctrl+D收藏本页 你会得到大惊喜!!