Drug-like Properties 2024 pdf epub mobi 电子书 图书描述 Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become a drug product. Understanding ADME/Tox...
Drug-like Properties Concepts, Structure Design and Methods from ADME to Toxicity Optimization-[1]-[Edward Kerns, Li Di] 来自淘豆网www.taodocs.com转载请标明出处. 文档信息 页数:549 收藏数:0 顶次数:0 上传人:联系 文件大小:6.55 MB 时间:2017-07-16...
Optimizing the "Drug-Like" Properties of Leads in Drug Discovery 2024 pdf epub mobi 用户评价 评分☆☆☆ 评分☆☆☆ 评分☆☆☆ 评分☆☆☆ 评分☆☆☆ Optimizing the "Drug-Like" Properties of Leads in Drug Discovery 2024 pdf epub mobi 电子书 Optimizing the "Drug-Like...
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The authors describe how properties affect in vivo pharmacological activity and impact in vitro assays. Individual drug-like properties are discussed from a practical point of view, such as solubility, permeability and metabolic stability, with regard to fundamental understanding, applications of ...
This is an excellent book on concepts and methods of drug-like properties. Google Scholar Gobeau, N., Stringer, R., De Buck, S., Tuntland, T. & Faller, B. Evaluation of the GastroPlus Advanced Compartmental and Transit (ACAT) model in early discovery. Pharm. Res. 33, 2126–2139 ...
J. Drug-like properties: guiding principles for the design of natural product libraries. J. Nat. Prod. 75, 72–81 (2012). This is a description of how screening collections can be prepared from natural-product extracts that are enriched with compounds that have physicochemical properties typical...
Drug-Like Properties Li Di and Edward H. Kerns Second Edition • 2016 Book Pharmacology in Drug Discovery and Development Terry P. Kenakin Second Edition • 2017 Book Synthesis of Best-Seller Drugs Ruben Vardanyan and Victor Hruby 2016 Book Mandell, Douglas, and Bennett's Principles and Pra...
Drugs like colchicine (122) that have systemic action are also particularly eligible for repurposing. It should be noted that no therapeutic interventions are devoid of side effects: onco-cardiology effects and the effect of chemotherapy are growing concerns of cancer patients in remission (123). ...
A. Recognizing molecules with drug-like properties. Curr. Opin. Chem. Biol. 3, 384–387 (1999). Article CAS PubMed Google Scholar Leeson, P. D. & Springthorpe, B. The influence of drug-like concepts on decision-making in medicinal chemistry. Nat. Rev. Drug Discov. 6, 881–890 (...