Drug-like Properties 2025 pdf epub mobi 电子书 图书描述 Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become a drug product. Understanding ADME/Tox...
Optimizing the "Drug-Like" Properties of Leads in Drug Discovery 2025 pdf epub mobi 用户评价 评分☆☆☆ 评分☆☆☆ 评分☆☆☆ 评分☆☆☆ 评分☆☆☆ Optimizing the "Drug-Like" Properties of Leads in Drug Discovery 2025 pdf epub mobi 电子书 分享链接facebook linkedin...
The authors describe how properties affect in vivo pharmacological activity and impact in vitro assays. Individual drug-like properties are discussed from a practical point of view, such as solubility, permeability and metabolic stability, with regard to fundamental understanding, applications of prop...
Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization, Second Edition, provides scientists and students the background and tools to understand, discover, and develop optimal clinical candidates. This valuable resource explores physiochemical properties, including ...
This is an excellent book on concepts and methods of drug-like properties. Google Scholar Gobeau, N., Stringer, R., De Buck, S., Tuntland, T. & Faller, B. Evaluation of the GastroPlus Advanced Compartmental and Transit (ACAT) model in early discovery. Pharm. Res. 33, 2126–2139 ...
J. Drug-like properties: guiding principles for the design of natural product libraries. J. Nat. Prod. 75, 72–81 (2012). This is a description of how screening collections can be prepared from natural-product extracts that are enriched with compounds that have physicochemical properties typical...
Dendrimers are spherical tree-like branched synthetic macromolecules possessing unique structural and topological features and are built around a linear polymeric core. They show biomolecule-like properties, a high degreThese cationic PAMAM dendrimers possess an ...
Since many potential drugs are eliminated from further development because of poor PK properties, drug discovery programs now incorporate early ADME screens for desirable 'drug-like' properties to optimize the selection of successful candidates. These predictive ADME approaches include in silico models, ...
AbstractforTargeting polyelectrolyte networks in purulent body fluids to modulate bactericidal properties of some antibiotics | Full Text | References | PDF (2.8 MB) 69 Views 9 CrossRef citations Altmetric Article Molecular analysis of multidrug resistance in clinical isolates of Shigella spp. from 20...
extend fragments in any direction without human bias. That is why structures in our data set are more spherical than structures from other libraries designed by medicinal chemists. The results presented here indicate that SECSE can generate structures with suitable druglike properties and diverse ...