Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization, Second Edition,provides scientists and students the background and tools to understand, discover, and develop optimal clinical candidates. This valuable resource explores physiochemical properties, including solubility ...
et al. Improvement of drug-like properties of peptides: the somatostatin paradigm. Expert Opin. Drug Discov. 5, 655–671 (2010). Article CAS PubMed Google Scholar Jevsevar, S., Kunstelj, M. & Porekar, V. G. PEGylation of therapeutic proteins. Biotechnol. J. 5, 113–128 (2010)...
Drug-like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization 1st Edition - July 26, 2010 Authors:Li Di, Edward H Kerns Language: English eBook ISBN:9780080951621 9 7 8 - 0 - 0 8 - 0 9 5 1 6 2 - 1 ...
15. Li Z et al, “Development and inhalation properties of Amikacin Liposome Inhalation Suspension (ALIS) for treatment of Mycobacterium avium complex (MAC) lung infections”. Drug Delivery to the Lungs Conference, Dec 2019. 16. “Applying Human Factors and Usability Engineering to Medical Devices...
HADS is used in general medical settings, including occupational health, with sound psychometric properties [70]. The Assessment Severity Index (ASI) is widely used to address the severity of substance use, health and social problems and the need of treatment. ASI holds 7 key domains: medical ...
•以全面的动物和人体数据为指导,这些数据广泛关注制剂的特性和动物的适宜性,以及(Is guided by a comprehensive set of animal and human data that focus broadly on the properties of the agent and the suitability of the animal, and) •允许在临床使用的...
Even if we are focusing on the uptake transporters within this commentary, one should keep in mind, that there are also various efflux transporters expressed within the BBB like ABCB1 (P-glycoprotein; P-gp), ABCG2 (BCRP) and various ABCCs (MRPs) that share neurosteroids as substrates and...
•以全面的动物和人体数据为指导,这些数据广泛关注制剂的特性和动物的适宜性,以及(Is guided by a comprehensive set of animal and human data that focus broadly on the properties of the agent and the suitability of the animal, and) •允许在临床使用的背景下对数据进行解释(Permits data interpretation...
(1990). Receptor-mediated endocytosis: Mechanisms, biologic function, and molecular properties. In: Hepatology. A Textbook of liver Disease. (2nd Ed.) Zakim D, Boyer T D, eds. W. B. Saunders, Philadelphia. If the compound is administered subcutaneously, the mannose-terminated dextran will ...
The crosslinking process reduced mucoadhesiveness and antifungal activity but significantly enhanced the mechanical properties and stability and enabled prolonged drug release. Keywords: sodium alginate; pectin; posaconazole; crosslinking process; buccal film Graphical Abstract 1. Introduction The most natural...